Ultrasonic absorption frequency dependence of two widely used anti-cancer drugs: doxorubicin and daunorubicin

Low intensity ultrasound (approximately 10 −6 W cm −2) in the frequency range 0.5–6.0 MHz was employed to investigate the ultrasound absorption properties of doxorubicin (DOX) at several temperatures. At physiological temperatures, we found enhanced ultrasound absorption from DOX, and its closely re...

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Bibliographic Details
Published in:Ultrasonics 1993, Vol.31 (6), p.447-450
Main Authors: Tata, D.B., Hahn, G., Dunn, F.
Format: Article
Language:English
Subjects:
Absorption
absorption properties
anti-cancer drugs
Daunorubicin
Doxorubicin
Temperature
Ultrasonics
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Summary:Low intensity ultrasound (approximately 10 −6 W cm −2) in the frequency range 0.5–6.0 MHz was employed to investigate the ultrasound absorption properties of doxorubicin (DOX) at several temperatures. At physiological temperatures, we found enhanced ultrasound absorption from DOX, and its closely related analogue daunorubicin (DNR), in the upper kilohertz frequency range. The findings do not conform to classical theory of ultrasound absorption, thus suggesting an ultrasound coupling with the drug molecules via structural and/or chemical relaxation processes. The absorption spectra are analysed from the point of view of the non-classical theory of sound absorption due to physical and/or chemical relaxations. Only one spectral difference between the two anti-cancer agents is observed, around 2 MHz, and may be attributed to the sole difference in the chemical make-up of the side chain of the two antibiotics.
ISSN:0041-624X
1874-9968
DOI:10.1016/0041-624X(93)90054-4