The GABA-ergic system: a locus of benzodiazepine action

gamma -Aminobutyric acid is regarded as one of the major inhibitory amino acid transmitters in the mammalian brain. In most regions of the brain, GABA is associated with local inhibitory neurons and only in two regions is GABA associated with longer projections. The present article describes how int...

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Bibliographic Details
Published in:Annual review of neuroscience 1985-01, Vol.8 (1), p.21-44
Main Authors: TALIMAN, J. F, GALLAGER, D. W
Format: Article
Language:English
Subjects:
Animals
Anti-Anxiety Agents - metabolism
Anti-Anxiety Agents - pharmacology
Benzodiazepines
Biological and medical sciences
brain
Brain - drug effects
Brain - metabolism
Brain Chemistry
Carbolines - pharmacology
Chemical Phenomena
Chemistry
gamma -aminobutyric acid
gamma-Aminobutyric Acid - pharmacology
gamma-Aminobutyric Acid - physiology
Humans
Mammalia
Medical sciences
Molecular Conformation
Neuropharmacology
Pharmacology. Drug treatments
Picrotoxin - pharmacology
Psycholeptics: tranquillizer, neuroleptic
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Rats
Receptors, GABA-A - analysis
Receptors, GABA-A - drug effects
Receptors, GABA-A - physiology
reviews
Synaptic Transmission
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Description
Summary:gamma -Aminobutyric acid is regarded as one of the major inhibitory amino acid transmitters in the mammalian brain. In most regions of the brain, GABA is associated with local inhibitory neurons and only in two regions is GABA associated with longer projections. The present article describes how interaction of binding sites for GABA, benzodiazepines (BDZ), and chloride channel blockers (picrotoxin, TBPS) results in the pharmacological activities of these compounds.
ISSN:0147-006X
1545-4126
DOI:10.1146/annurev.ne.08.030185.000321