Ontogenesis of gastrin cells in the pyloric antrum and duodenum of the mouse

Ontogenesis of gastrin cells was studied in the pyloroduodenal mucosa of the mouse using anti-human G17 serum, R-1301, and anti-human G34(1-15) serum, R-2703. R-1301-immunostained cells first appeared in the pyloric mucosa of 14-day-old fetuses. Cells stained with both R-1301 and R-2703 appeared imm...

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Bibliographic Details
Published in:Cell and tissue research 1985-03, Vol.239 (3), p.531-535
Main Authors: Kataoka, K, Miura, J, Takeoka, Y, Kusumoto, Y, Yanaihara, N
Format: Article
Language:English
Subjects:
Age Factors
Animals
Duodenum - cytology
Duodenum - growth & development
Duodenum - metabolism
Gastric Mucosa - metabolism
Gastrins - metabolism
Immunologic Techniques
Mice
Mice, Inbred ICR - growth & development
Stomach - cytology
Stomach - growth & development
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Summary:Ontogenesis of gastrin cells was studied in the pyloroduodenal mucosa of the mouse using anti-human G17 serum, R-1301, and anti-human G34(1-15) serum, R-2703. R-1301-immunostained cells first appeared in the pyloric mucosa of 14-day-old fetuses. Cells stained with both R-1301 and R-2703 appeared immediately after birth, and gradually increased in number to the adult level. Most R-1301-reactive cells were also reactive to R-2703, whereas some cells that reacted with R-1301 exhibited very weak or no reaction with R-2703. The discrepancy between these two immunoreactivities is discussed. In the duodenum, a considerable number of R-1301-reactive cells were present from the perinatal stage and through out adult development. A few R-2703-reactive cells were seen in the duodenum of young mice but not of the adult.
ISSN:0302-766X
1432-0878
DOI:10.1007/bf00219231