Cloning of B7-2: A CTLA-4 Counter-Receptor that Costimulates Human T Cell Proliferation

Although presentation of antigen to the T cell receptor is necessary for the initiation of an immune response, additional molecules expressed on antigen-presenting cells deliver essential costimulatory signals. T cell activation, in the absence of costimulation, results in T cell anergy. The B7-1 pr...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1993-11, Vol.262 (5135), p.909-911
Main Authors: Freeman, Gordon J., Gribben, John G., Boussiotis, Vassiliki A., Ng, Judy W., Restivo, Vincent A., Lombard, Lisa A., Gray, Gary S., Nadler, Lee M.
Format: Article
Language:English
Subjects:
Abatacept
Amino Acid Sequence
Amino acids
Animals
Antigen receptors, T cell
Antigens, CD
Antigens, Differentiation - metabolism
B lymphocytes
B-Lymphocytes - immunology
B-Lymphocytes - metabolism
B7-1 Antigen - chemistry
B7-1 Antigen - genetics
B7-1 Antigen - immunology
B7-1 Antigen - metabolism
B7-2 Antigen
Biological and medical sciences
CD28 Antigens - metabolism
Cell Line
Cell lines
Cloning, Molecular
Complementary DNA
COS cells
CTLA-4 Antigen
DNA, Complementary - genetics
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Immune response
Immunobiology
Immunoconjugates
Lymphocyte Activation
Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation
Membrane Glycoproteins
Messenger RNA
Molecular Sequence Data
Receptors
RNA
Sequence Alignment
Signal Transduction
T cell antigen receptors
T cells
T lymphocytes
T-Lymphocytes - immunology
Transfection
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Summary:Although presentation of antigen to the T cell receptor is necessary for the initiation of an immune response, additional molecules expressed on antigen-presenting cells deliver essential costimulatory signals. T cell activation, in the absence of costimulation, results in T cell anergy. The B7-1 protein is a costimulator molecule that regulates interleukin-2 (IL-2) secretion by signaling through the pathway that uses CD28 and CTLA-4 (hereafter referred to as the CD28 pathway). We have cloned a counter-receptor of CD28 and CTLA-4, termed B7-2. Although only 26 percent identical to B7-1, B7-2 also costimulates IL-2 production and T cell proliferation. Unlike B7-1, B7-2 messenger RNA is constitutively expressed in unstimulated B cells. It is likely that B7-2 provides a critical early costimulatory signal determining if the T cell will contribute to an immune response or become anergic.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.7694363