Association between Antibody to the Chlamydial Heat-Shock Protein and Tubal Infertility

To determine the prevalence of antibody to Chlamydia heat-shock protein 60 (C-hsp60) in women with tubal infertility, an ELISA using purified recombinant C-hsp60 was developed. Antibody to C. trachomatis was present in 32 (72.7%) of 44 women with tubal infertility compared with 9 (32.1%) of28 with o...

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Bibliographic Details
Published in:The Journal of infectious diseases 1993-11, Vol.168 (5), p.1236-1240
Main Authors: Toye, Baldwin, Laferrière, Craig, Claman, Paul, Jessamine, Peter, Peeling, Rosanna
Format: Article
Language:English
Subjects:
Antibodies
Antibodies, Bacterial - blood
Antibody formation
Antigens
Biological and medical sciences
Birth control
Causality
Chaperonin 60
Chlamydia
Chlamydia Infections - complications
Chlamydia Infections - diagnosis
Chlamydia Infections - immunology
Chlamydia trachomatis
Chlamydia trachomatis - immunology
Cross Reactions
Ectopic pregnancy
Enzyme linked immunosorbent assay
Enzyme-Linked Immunosorbent Assay - methods
Fallopian tube diseases
Fallopian Tube Diseases - etiology
Female
Gynecology. Andrology. Obstetrics
Heat shock proteins
Heat-Shock Proteins - genetics
Heat-Shock Proteins - immunology
Humans
Infections
Infertility, Female - etiology
Major Articles
Medical sciences
Pathogenesis
Recombinant Proteins - immunology
Sterility. Assisted procreation
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Summary:To determine the prevalence of antibody to Chlamydia heat-shock protein 60 (C-hsp60) in women with tubal infertility, an ELISA using purified recombinant C-hsp60 was developed. Antibody to C. trachomatis was present in 32 (72.7%) of 44 women with tubal infertility compared with 9 (32.1%) of28 with other causes of infertility and 55 (28.9%) of 190 pregnant women (P < .001). Among the seropositive women, antibody to C-hsp60 was present in 26 (81.3%) of 32 women with tubal infertility compared with 0 of9 with other causes of infertility and 9 (16.4%) of 55 pregnant women (P < .001). The C-hsp60 ELISA detected Chlamydia-associated tubal infertility in infertile women with a sensitivity of 81.3% and a specificity of 97.5%. There is a strong association between antibody response to the C-hsp60 and the development of Chlamydia-associated tubal infertility. Thus, a C-hsp60 ELISA may be useful as a predictor for poor fertility outcome.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/168.5.1236