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Association between Antibody to the Chlamydial Heat-Shock Protein and Tubal Infertility
To determine the prevalence of antibody to Chlamydia heat-shock protein 60 (C-hsp60) in women with tubal infertility, an ELISA using purified recombinant C-hsp60 was developed. Antibody to C. trachomatis was present in 32 (72.7%) of 44 women with tubal infertility compared with 9 (32.1%) of28 with o...
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| Published in: | The Journal of infectious diseases 1993-11, Vol.168 (5), p.1236-1240 |
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| Main Authors: | , , , , |
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| Language: | English |
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| container_end_page | 1240 |
| container_issue | 5 |
| container_start_page | 1236 |
| container_title | The Journal of infectious diseases |
| container_volume | 168 |
| creator | Toye, Baldwin Laferrière, Craig Claman, Paul Jessamine, Peter Peeling, Rosanna |
| description | To determine the prevalence of antibody to Chlamydia heat-shock protein 60 (C-hsp60) in women with tubal infertility, an ELISA using purified recombinant C-hsp60 was developed. Antibody to C. trachomatis was present in 32 (72.7%) of 44 women with tubal infertility compared with 9 (32.1%) of28 with other causes of infertility and 55 (28.9%) of 190 pregnant women (P < .001). Among the seropositive women, antibody to C-hsp60 was present in 26 (81.3%) of 32 women with tubal infertility compared with 0 of9 with other causes of infertility and 9 (16.4%) of 55 pregnant women (P < .001). The C-hsp60 ELISA detected Chlamydia-associated tubal infertility in infertile women with a sensitivity of 81.3% and a specificity of 97.5%. There is a strong association between antibody response to the C-hsp60 and the development of Chlamydia-associated tubal infertility. Thus, a C-hsp60 ELISA may be useful as a predictor for poor fertility outcome. |
| doi_str_mv | 10.1093/infdis/168.5.1236 |
| format | article |
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Antibody to C. trachomatis was present in 32 (72.7%) of 44 women with tubal infertility compared with 9 (32.1%) of28 with other causes of infertility and 55 (28.9%) of 190 pregnant women (P < .001). Among the seropositive women, antibody to C-hsp60 was present in 26 (81.3%) of 32 women with tubal infertility compared with 0 of9 with other causes of infertility and 9 (16.4%) of 55 pregnant women (P < .001). The C-hsp60 ELISA detected Chlamydia-associated tubal infertility in infertile women with a sensitivity of 81.3% and a specificity of 97.5%. There is a strong association between antibody response to the C-hsp60 and the development of Chlamydia-associated tubal infertility. Thus, a C-hsp60 ELISA may be useful as a predictor for poor fertility outcome.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/168.5.1236</identifier><identifier>PMID: 7901289</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Antibodies ; Antibodies, Bacterial - blood ; Antibody formation ; Antigens ; Biological and medical sciences ; Birth control ; Causality ; Chaperonin 60 ; Chlamydia ; Chlamydia Infections - complications ; Chlamydia Infections - diagnosis ; Chlamydia Infections - immunology ; Chlamydia trachomatis ; Chlamydia trachomatis - immunology ; Cross Reactions ; Ectopic pregnancy ; Enzyme linked immunosorbent assay ; Enzyme-Linked Immunosorbent Assay - methods ; Fallopian tube diseases ; Fallopian Tube Diseases - etiology ; Female ; Gynecology. Andrology. Obstetrics ; Heat shock proteins ; Heat-Shock Proteins - genetics ; Heat-Shock Proteins - immunology ; Humans ; Infections ; Infertility, Female - etiology ; Major Articles ; Medical sciences ; Pathogenesis ; Recombinant Proteins - immunology ; Sterility. Assisted procreation</subject><ispartof>The Journal of infectious diseases, 1993-11, Vol.168 (5), p.1236-1240</ispartof><rights>Copyright 1993 The University of Chicago</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-ee8cdd81b263992f6d939bfc05bd3981051826971f4eaef954feaf419532b95e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4067711$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7901289$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Toye, Baldwin</creatorcontrib><creatorcontrib>Laferrière, Craig</creatorcontrib><creatorcontrib>Claman, Paul</creatorcontrib><creatorcontrib>Jessamine, Peter</creatorcontrib><creatorcontrib>Peeling, Rosanna</creatorcontrib><title>Association between Antibody to the Chlamydial Heat-Shock Protein and Tubal Infertility</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>To determine the prevalence of antibody to Chlamydia heat-shock protein 60 (C-hsp60) in women with tubal infertility, an ELISA using purified recombinant C-hsp60 was developed. Antibody to C. trachomatis was present in 32 (72.7%) of 44 women with tubal infertility compared with 9 (32.1%) of28 with other causes of infertility and 55 (28.9%) of 190 pregnant women (P < .001). Among the seropositive women, antibody to C-hsp60 was present in 26 (81.3%) of 32 women with tubal infertility compared with 0 of9 with other causes of infertility and 9 (16.4%) of 55 pregnant women (P < .001). The C-hsp60 ELISA detected Chlamydia-associated tubal infertility in infertile women with a sensitivity of 81.3% and a specificity of 97.5%. There is a strong association between antibody response to the C-hsp60 and the development of Chlamydia-associated tubal infertility. Thus, a C-hsp60 ELISA may be useful as a predictor for poor fertility outcome.</description><subject>Antibodies</subject><subject>Antibodies, Bacterial - blood</subject><subject>Antibody formation</subject><subject>Antigens</subject><subject>Biological and medical sciences</subject><subject>Birth control</subject><subject>Causality</subject><subject>Chaperonin 60</subject><subject>Chlamydia</subject><subject>Chlamydia Infections - complications</subject><subject>Chlamydia Infections - diagnosis</subject><subject>Chlamydia Infections - immunology</subject><subject>Chlamydia trachomatis</subject><subject>Chlamydia trachomatis - immunology</subject><subject>Cross Reactions</subject><subject>Ectopic pregnancy</subject><subject>Enzyme linked immunosorbent assay</subject><subject>Enzyme-Linked Immunosorbent Assay - methods</subject><subject>Fallopian tube diseases</subject><subject>Fallopian Tube Diseases - etiology</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Heat shock proteins</subject><subject>Heat-Shock Proteins - genetics</subject><subject>Heat-Shock Proteins - immunology</subject><subject>Humans</subject><subject>Infections</subject><subject>Infertility, Female - etiology</subject><subject>Major Articles</subject><subject>Medical sciences</subject><subject>Pathogenesis</subject><subject>Recombinant Proteins - immunology</subject><subject>Sterility. 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Andrology. Obstetrics</topic><topic>Heat shock proteins</topic><topic>Heat-Shock Proteins - genetics</topic><topic>Heat-Shock Proteins - immunology</topic><topic>Humans</topic><topic>Infections</topic><topic>Infertility, Female - etiology</topic><topic>Major Articles</topic><topic>Medical sciences</topic><topic>Pathogenesis</topic><topic>Recombinant Proteins - immunology</topic><topic>Sterility. Assisted procreation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Toye, Baldwin</creatorcontrib><creatorcontrib>Laferrière, Craig</creatorcontrib><creatorcontrib>Claman, Paul</creatorcontrib><creatorcontrib>Jessamine, Peter</creatorcontrib><creatorcontrib>Peeling, Rosanna</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Toye, Baldwin</au><au>Laferrière, Craig</au><au>Claman, Paul</au><au>Jessamine, Peter</au><au>Peeling, Rosanna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between Antibody to the Chlamydial Heat-Shock Protein and Tubal Infertility</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1993-11-01</date><risdate>1993</risdate><volume>168</volume><issue>5</issue><spage>1236</spage><epage>1240</epage><pages>1236-1240</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>To determine the prevalence of antibody to Chlamydia heat-shock protein 60 (C-hsp60) in women with tubal infertility, an ELISA using purified recombinant C-hsp60 was developed. Antibody to C. trachomatis was present in 32 (72.7%) of 44 women with tubal infertility compared with 9 (32.1%) of28 with other causes of infertility and 55 (28.9%) of 190 pregnant women (P < .001). Among the seropositive women, antibody to C-hsp60 was present in 26 (81.3%) of 32 women with tubal infertility compared with 0 of9 with other causes of infertility and 9 (16.4%) of 55 pregnant women (P < .001). The C-hsp60 ELISA detected Chlamydia-associated tubal infertility in infertile women with a sensitivity of 81.3% and a specificity of 97.5%. There is a strong association between antibody response to the C-hsp60 and the development of Chlamydia-associated tubal infertility. Thus, a C-hsp60 ELISA may be useful as a predictor for poor fertility outcome.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>7901289</pmid><doi>10.1093/infdis/168.5.1236</doi><tpages>5</tpages></addata></record> |
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| ispartof | The Journal of infectious diseases, 1993-11, Vol.168 (5), p.1236-1240 |
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| language | eng |
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| source | Oxford University Press:Jisc Collections:Oxford Journal Archive: Access period 2024-2025 |
| subjects | Antibodies Antibodies, Bacterial - blood Antibody formation Antigens Biological and medical sciences Birth control Causality Chaperonin 60 Chlamydia Chlamydia Infections - complications Chlamydia Infections - diagnosis Chlamydia Infections - immunology Chlamydia trachomatis Chlamydia trachomatis - immunology Cross Reactions Ectopic pregnancy Enzyme linked immunosorbent assay Enzyme-Linked Immunosorbent Assay - methods Fallopian tube diseases Fallopian Tube Diseases - etiology Female Gynecology. Andrology. Obstetrics Heat shock proteins Heat-Shock Proteins - genetics Heat-Shock Proteins - immunology Humans Infections Infertility, Female - etiology Major Articles Medical sciences Pathogenesis Recombinant Proteins - immunology Sterility. Assisted procreation |
| title | Association between Antibody to the Chlamydial Heat-Shock Protein and Tubal Infertility |
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