Structure of two new oligosaccharides isolated from human milk: Sialylated lacto- N-fucopentaoses I and II

The structures of two minor oligosaccharides isolated from human milk have been investigated. By using f.a.b.-mass spectrometry, methylation analysis, and partial formolysis as the principal methods of structural investigation, these oligosaccharides were identified as IV 2-α-Fuc-III 6-α-NeuAc-LcOse...

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Bibliographic Details
Published in:Carbohydrate research 1985-03, Vol.137, p.127-138
Main Authors: Wieruszeski, Jean-Michel, Chekkor, Abdelmalek, Bouquelet, Stéphane, Montreuil, Jean, Strecker, Gérard, Peter-Katalinic, Jasna, Egge, Heinz
Format: Article
Language:English
Subjects:
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Carbohydrates
Chromatography, Paper
Female
Fundamental and applied biological sciences. Psychology
Humans
Mass Spectrometry
Methylation
Milk, Human - analysis
Oligosaccharides - analysis
Other biological molecules
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Summary:The structures of two minor oligosaccharides isolated from human milk have been investigated. By using f.a.b.-mass spectrometry, methylation analysis, and partial formolysis as the principal methods of structural investigation, these oligosaccharides were identified as IV 2-α-Fuc-III 6-α-NeuAc-LcOse 4 and IV 3-α-NeuAc-III 4-α-Fuc-LcOse 4. This latter oligosaccharide has been recently found to be the carbohydrate moiety of a ganglioside isolated from a colorectal carcinoma cell-line (see ref. 12).
ISSN:0008-6215
1873-426X
DOI:10.1016/0008-6215(85)85154-5