Treatment of essential hypertension: changes in blood pressure echocardiography and electrocardiography on three therapeutic regimes

Forty-three patients with essential hypertension were randomly allocated to one of the following treatment regimes; - atenolol, atenolol and hydralazine or methyl dopa. Blood pressure fell into the normal range at 3 months and was similar in all 3 groups. Blood pressure remained controlled over the...

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Bibliographic Details
Published in:European journal of clinical pharmacology 1985, Vol.28 (2), p.119-124
Main Authors: RUSSELL, G. I, POHL, J. E. F, BALDWIN, J, BING, R. F, HEAGERTY, A. M, THURSTON, H, SWALES, J. D
Format: Article
Language:English
Subjects:
Adult
Antihypertensive agents
Biological and medical sciences
Blood Pressure - drug effects
Cardiomegaly - physiopathology
Cardiovascular system
Drug Administration Schedule
Echocardiography
Electrocardiography
Humans
Hypertension - drug therapy
Hypertension - physiopathology
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Random Allocation
Vasodilator Agents - administration & dosage
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Summary:Forty-three patients with essential hypertension were randomly allocated to one of the following treatment regimes; - atenolol, atenolol and hydralazine or methyl dopa. Blood pressure fell into the normal range at 3 months and was similar in all 3 groups. Blood pressure remained controlled over the period of study. M-mode echocardiography was assessed initially, at 3, 6 and 12 months. All groups showed a fall in the measured indices towards the normal range with a significant reduction in left ventricular wall thickness at 3 months in the methyl dopa group and left ventricular mass in the atenolol group alone of 6 months. In conclusion, no one treatment regime appeared to have sustained advantages over another and none of the groups showed any deterioration on echocardiographic criteria during the study.
ISSN:0031-6970
1432-1041
DOI:10.1007/BF00609677