Neonatal thyrotoxicosis treated with exchange transfusion and Lugol's iodine

An infant with neonatal thyrotoxicosis was born to a mother who had become euthyroid after subtotal thyroidectomy for Graves' disease. Exchange transfusion resulted in a 50% decrease of serum thyroxine levels and thyroid stimulating immunoglobulins. After 10 days mild thyrotoxic signs reappeare...

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Bibliographic Details
Published in:European journal of pediatrics 1985-03, Vol.143 (4), p.317-319
Main Authors: WIT, J. M, GERARDS, L. J, VEMEULEN-MEINERS, C, BRUINSE, H. W
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Endocrinopathies
Exchange Transfusion, Whole Blood
Female
Humans
Hyperthyroidism - congenital
Hyperthyroidism - therapy
Immunoglobulin G - analysis
Immunoglobulins, Thyroid-Stimulating
Infant, Newborn
Iodides - therapeutic use
Malignant tumors
Medical sciences
Milk, Human - analysis
Solutions
Thyroid Function Tests
Thyroid. Thyroid axis (diseases)
Thyroxine - blood
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Summary:An infant with neonatal thyrotoxicosis was born to a mother who had become euthyroid after subtotal thyroidectomy for Graves' disease. Exchange transfusion resulted in a 50% decrease of serum thyroxine levels and thyroid stimulating immunoglobulins. After 10 days mild thyrotoxic signs reappeared with high serum thyroxine levels, which were treated successfully with Lugol's iodine for 4 weeks. TSI was undetectable at 7 weeks of age. TSI was present in breast milk.
ISSN:0340-6199
1432-1076
DOI:10.1007/BF00442312