OLIGOMYCIN F, A NEW IMMUNOSUPPRESSIVE HOMOLOGUE OF OLIGOMYCIN A

Oligomycin F, a new homologue of oligomycin A (1), was isolated from a Streptomyces species and structure 2 was deduced by NMR methods. Compound 2 is highly active against plant pathogenic fungi and is an extremely potent suppressive agent for various immunological systems.

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Bibliographic Details
Published in:Journal of antibiotics 1993/09/25, Vol.46(9), pp.1334-1341
Main Authors: LAATSCH, HARTMUT, KELLNER, MICHAEL, WOLF, GERHARD, LEE, YONG-SE, HANSSKE, FRITZ, KONETSCHNY-RAPP, SILVIA, PESSARA, ULRICH, SCHEUER, WERNER, STOCKINGER, HUBERTUS
Format: Article
Language:English
Subjects:
Animals
Antifungal Agents - chemistry
Antifungal Agents - isolation & purification
Antifungal Agents - pharmacology
Biological and medical sciences
Cell Division - drug effects
Cells, Cultured
Fermentation
Humans
Immunoglobulin G - biosynthesis
Immunomodulators
Immunosuppressive Agents - chemistry
Immunosuppressive Agents - isolation & purification
Immunosuppressive Agents - pharmacology
Lymphocytes - drug effects
Lymphocytes - metabolism
Magnetic Resonance Spectroscopy
Medical sciences
Mice
Molecular Structure
Oligomycins - chemistry
Oligomycins - isolation & purification
Oligomycins - pharmacology
Pharmacology. Drug treatments
Spleen - cytology
Spleen - drug effects
Spleen - metabolism
Streptomyces - chemistry
Tumor Cells, Cultured
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Description
Summary:Oligomycin F, a new homologue of oligomycin A (1), was isolated from a Streptomyces species and structure 2 was deduced by NMR methods. Compound 2 is highly active against plant pathogenic fungi and is an extremely potent suppressive agent for various immunological systems.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.46.1334