CLINICAL STUDIES WITH CEFOPERAZONE IN THE BILIARY DISEASE

1. The concentration of cefoperazone (CPZ) in serum and bile was estimated after intravenous drip infusion of 1g of the drug in 11 patients, who have performed cholecystectomy, choledocholithotomy and T-tube drainage for gallstone diseases. Administration of cefazolin (CEZ) 1g was compared by the cr...

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Bibliographic Details
Published in:Japanese journal of antibiotics 1985/01/25, Vol.38(1), pp.128-132
Main Authors: ITOSE, KAORU, FURUKAWA, MASATO, OHTSUBO, MITSUJI, YAMADA, RYUHEI, MAEDA, SHIGERU, ITOH, SHINICHIRO, NAKATA, TOSHINORI, MORINAGA, TOSHIYUKI
Format: Article
Language:Japanese
Subjects:
Adult
Aged
Bacterial Infections - prevention & control
Bile - metabolism
Cefazolin - blood
Cefazolin - metabolism
Cefoperazone - administration & dosage
Cefoperazone - blood
Cefoperazone - metabolism
Cholelithiasis - surgery
Female
Humans
Infusions, Parenteral
Male
Middle Aged
Surgical Wound Infection - prevention & control
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Summary:1. The concentration of cefoperazone (CPZ) in serum and bile was estimated after intravenous drip infusion of 1g of the drug in 11 patients, who have performed cholecystectomy, choledocholithotomy and T-tube drainage for gallstone diseases. Administration of cefazolin (CEZ) 1g was compared by the cross over method. 2. After 1g intravenous drip infusion of CPZ, the mean serum concentration was 88.3±24μg/ml at 1 hour, 52±11.7μg/ml at 2 hours and 36.5±10μg/ml at 4 hours. The maintenance period of serum concentration was inclined to be longer in CPZ than in CEZ. 3. After 1g intravenous drip infusion of CPZ, the mean bile concentration reached to810±459μg/ml in 2 hours and it was maintained as high as 562±319μg/ml even after 4 hours. On the other hand, after 1g intravenous drip infusion of CEZ, the mean bile concentration was only 28.7±26ug/ml in 1 hour and was low level in the progress. 4. As compared with the highest concentration of CPZ and CEZ in same patient, the mean bile concentration of CPZ (942±525μg/ml) was about 30 times higher than that of CEZ (28.6±26.3μg/ml). 5. There was no difference in the group of Gram-positive cocci between minimum inhibitory concentration (MIC) of CPZ and that of CEZ. While MIC of CEZ in the group of Gram-negative bacilli was from 0.78 to over 400μg/ml, MIC of CPZ in that group was from 0.10 to 50μg/ml. The value in CPZ was lower than that in CEZ at all strains. No side effects was seen in all patients.
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.38.128