Positron Emission Tomography in Schizophrenic Patients With and Without Neuroleptic Medication

Positron emission tomography using [18F]2-fluoro-2-deoxy-d-glucose was performed in nine chronic schizophrenic patients both when medication-free and when medicated with neuroleptics. Total brain cortex, temporal cortex, and basal ganglia glucose use was significantly increased with medication; howe...

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Bibliographic Details
Published in:Journal of cerebral blood flow and metabolism 1985-06, Vol.5 (2), p.201-206
Main Authors: DeLisi, Lynn E., Holcomb, Henry H., Cohen, Robert M., Pickar, David, Carpenter, William, Morihisa, John M., King, A. Catherine, Kessler, Robert, Buchsbaum, Monte S.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Adult and adolescent clinical studies
Antipsychotic Agents - therapeutic use
Applied sciences
Biological and medical sciences
Caudate Nucleus - metabolism
Chronic Disease
Exact sciences and technology
Female
Glucose - metabolism
Humans
Male
Medical sciences
Other techniques and industries
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Schizophrenia - drug therapy
Schizophrenia - metabolism
Temporal Lobe - diagnostic imaging
Temporal Lobe - metabolism
Tomography, Emission-Computed
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Summary:Positron emission tomography using [18F]2-fluoro-2-deoxy-d-glucose was performed in nine chronic schizophrenic patients both when medication-free and when medicated with neuroleptics. Total brain cortex, temporal cortex, and basal ganglia glucose use was significantly increased with medication; however, there was no change in anterior/posterior metabolic gradients.
ISSN:0271-678X
1559-7016
DOI:10.1038/jcbfm.1985.26