Significance of Placental Findings in Early-Onset Group B Streptococcal Neonatal Sepsis

Assessment of placental pathology and its relationship to historical data, initial laboratory parameters, and outcome was undertaken in 22 cases of early-onset group B streptococcal sepsis of the neonate. Fourteen (64%) of the placentas demonstrated chorioamnionitis, six (27%) funisitis, and in nine...

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Bibliographic Details
Published in:Clinical pediatrics 1985-05, Vol.24 (5), p.256-258
Main Authors: Novak, Robert W., Platt, Marvin S.
Format: Article
Language:English
Subjects:
Bacterial diseases
Biological and medical sciences
Chorioamnionitis - etiology
Edema - etiology
Extraembryonic Membranes - pathology
Female
Fetal Diseases - etiology
Human bacterial diseases
Humans
Infant, Newborn
Infectious diseases
Inflammation - etiology
Male
Medical sciences
Placenta - pathology
Placenta Diseases - etiology
Pregnancy
Sex Factors
Streptococcal Infections - etiology
Streptococcus agalactiae
Time Factors
Umbilical Cord - pathology
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Summary:Assessment of placental pathology and its relationship to historical data, initial laboratory parameters, and outcome was undertaken in 22 cases of early-onset group B streptococcal sepsis of the neonate. Fourteen (64%) of the placentas demonstrated chorioamnionitis, six (27%) funisitis, and in nine (41%) gram stain demonstrated organisms within the membranes. Focal villous edema was observed in five (23%) cases and diffuse villous edema in four (18%). No placenta demonstrated chorangiosis. Placental inflammation was significantly (p < 0.05) associated with prematurity, prolonged rupture of membranes, and onset of symptoms at less than 3 hours of age. No placental change was significantly associated with outcome or with neutropenia, which was the only parameter assessed that appeared to have prognostic value.
ISSN:0009-9228
1938-2707
DOI:10.1177/000992288502400504