Global Occurrence of Plasmodium vivax-like Human Malaria Parasite

A Plasmodium vivax-like human malaria parasite was recently identified from Madang, a holoendemic malarious region in Papua New Guinea. The complete nucleotide sequence of the circumsporozoite (CS) protein gene of this parasite is presented here. The CS protein of this parasite has an 11-mer repeat...

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Bibliographic Details
Published in:The Journal of infectious diseases 1993-12, Vol.168 (6), p.1485-1489
Main Authors: Qari, Shoukat H., Shi, Va-Ping, Povoa, Marinete M., Alpers, Michael P., Deloron, Philippe, Murphy, Gerald S., Harjosuwarno, Slamet, Lal, Altar A.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Amino acids
Animals
Base Sequence
Biological and medical sciences
Blood
DNA
DNA, Protozoan
Fundamental and applied biological sciences. Psychology
Geographic regions
Humans
Major Articles
Malaria
Malaria, Vivax - parasitology
Molecular Sequence Data
Nucleotide sequences
Nucleotides
Parasites
Parasitism
Plasmodium vivax
Plasmodium vivax - classification
Plasmodium vivax - genetics
Protozoa
Protozoan Proteins - genetics
Repetitive Sequences, Nucleic Acid
Sequence Homology, Nucleic Acid
Sporozoites
Systematics. Geographical distribution. Morphology. Cytology
Tropical medicine
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Summary:A Plasmodium vivax-like human malaria parasite was recently identified from Madang, a holoendemic malarious region in Papua New Guinea. The complete nucleotide sequence of the circumsporozoite (CS) protein gene of this parasite is presented here. The CS protein of this parasite has an 11-mer repeat sequence and is different from the other known CS protein genes of human malaria parasites. However, it is identical to the CS protein gene of a monkey malaria parasite, Plasmodium simiovale. This P. vivax-like malaria parasite was found in Sepik, another malarious region of Papua New Guinea, and in Brazil, Indonesia, and Madagascar. No pure isolate of this parasite was identified. Specific oligonucleotide probes were used to determine relative proportion of the P. vivax-like parasite in P. vivax (type 1 and type 2) mixed field isolates. Compared with P. vivax or Plasmodium falciparum, the circumsporozoite protein of P. vivax-like parasites showed markedly less polymorphism.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/168.6.1485