Involvement of inflammatory mediators in macrophage antitumor activity

This review describes the potential role of macrophages in defense against cancer cells and the regulatory involvement of inflammatory mediators in this role. Interactions between macrophage‐derived cytokines (tumor necrosis factor a, interleukin‐1, IL‐6) and their interrelationships with eicosanoid...

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Bibliographic Details
Published in:Journal of leukocyte biology 1993-12, Vol.54 (6), p.613-626
Main Authors: Bonta, Ivan L, Ben-Efraim, Shlomo
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - pharmacology
antitumor activity
Biological and medical sciences
cancer immunotherapy
cytokines
cytotoxicity
Cytotoxicity, Immunologic
eicosanoids
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Immunobiology
inflammatory mediators
Interleukin-1 - physiology
Interleukin-6 - physiology
interleukin‐1
interleukin‐6
lipoxygenase metabolites
macrophages
Macrophages - immunology
Macrophages - physiology
Mice
Monocytes, macrophages
Myeloid cells: ontogeny, maturation, markers, receptors
prostaglandin E2
tumor necrosis factor α
Tumor Necrosis Factor-alpha - physiology
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Summary:This review describes the potential role of macrophages in defense against cancer cells and the regulatory involvement of inflammatory mediators in this role. Interactions between macrophage‐derived cytokines (tumor necrosis factor a, interleukin‐1, IL‐6) and their interrelationships with eicosanoids (mainly the cyclooxygenase product prostaglandin E2 and some lipoxygenase metabolites) represent a network that controls the expression of antitumor activity of macrophages either in a cell‐to‐cell contact system between the effector and the target tumor cell or as cell‐free soluble products. Attention is given to the influence of tumor burden on production of cytokines and eicosanoids by macrophages and to the production of these mediators by tumor cells. Emphasis is placed on the roles of TNF‐α and PGE2 in links between inflammatory and antitumor functions of macrophages. Finally, the perspectives and still existing problems in clinical implications of macrophage‐derived cytokines are discussed in terms of a conceivable macrophage‐directed immunotherapy of cancer.
ISSN:0741-5400
1938-3673
DOI:10.1002/jlb.54.6.613