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Involvement of inflammatory mediators in macrophage antitumor activity
This review describes the potential role of macrophages in defense against cancer cells and the regulatory involvement of inflammatory mediators in this role. Interactions between macrophage‐derived cytokines (tumor necrosis factor a, interleukin‐1, IL‐6) and their interrelationships with eicosanoid...
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| Published in: | Journal of leukocyte biology 1993-12, Vol.54 (6), p.613-626 |
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| Main Authors: | , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c4843-d9ab17534410153ec57df1efd5fedb0a7a90a364deb64b341f805ce48c0d438e3 |
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| container_end_page | 626 |
| container_issue | 6 |
| container_start_page | 613 |
| container_title | Journal of leukocyte biology |
| container_volume | 54 |
| creator | Bonta, Ivan L Ben-Efraim, Shlomo |
| description | This review describes the potential role of macrophages in defense against cancer cells and the regulatory involvement of inflammatory mediators in this role. Interactions between macrophage‐derived cytokines (tumor necrosis factor a, interleukin‐1, IL‐6) and their interrelationships with eicosanoids (mainly the cyclooxygenase product prostaglandin E2 and some lipoxygenase metabolites) represent a network that controls the expression of antitumor activity of macrophages either in a cell‐to‐cell contact system between the effector and the target tumor cell or as cell‐free soluble products. Attention is given to the influence of tumor burden on production of cytokines and eicosanoids by macrophages and to the production of these mediators by tumor cells. Emphasis is placed on the roles of TNF‐α and PGE2 in links between inflammatory and antitumor functions of macrophages. Finally, the perspectives and still existing problems in clinical implications of macrophage‐derived cytokines are discussed in terms of a conceivable macrophage‐directed immunotherapy of cancer. |
| doi_str_mv | 10.1002/jlb.54.6.613 |
| format | article |
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Interactions between macrophage‐derived cytokines (tumor necrosis factor a, interleukin‐1, IL‐6) and their interrelationships with eicosanoids (mainly the cyclooxygenase product prostaglandin E2 and some lipoxygenase metabolites) represent a network that controls the expression of antitumor activity of macrophages either in a cell‐to‐cell contact system between the effector and the target tumor cell or as cell‐free soluble products. Attention is given to the influence of tumor burden on production of cytokines and eicosanoids by macrophages and to the production of these mediators by tumor cells. Emphasis is placed on the roles of TNF‐α and PGE2 in links between inflammatory and antitumor functions of macrophages. Finally, the perspectives and still existing problems in clinical implications of macrophage‐derived cytokines are discussed in terms of a conceivable macrophage‐directed immunotherapy of cancer.</description><identifier>ISSN: 0741-5400</identifier><identifier>EISSN: 1938-3673</identifier><identifier>DOI: 10.1002/jlb.54.6.613</identifier><identifier>PMID: 8245715</identifier><identifier>CODEN: JLBIE7</identifier><language>eng</language><publisher>Bethesda, MD: Society for Leukocyte Biology</publisher><subject>Animals ; Antineoplastic Agents - pharmacology ; antitumor activity ; Biological and medical sciences ; cancer immunotherapy ; cytokines ; cytotoxicity ; Cytotoxicity, Immunologic ; eicosanoids ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Humans ; Immunobiology ; inflammatory mediators ; Interleukin-1 - physiology ; Interleukin-6 - physiology ; interleukin‐1 ; interleukin‐6 ; lipoxygenase metabolites ; macrophages ; Macrophages - immunology ; Macrophages - physiology ; Mice ; Monocytes, macrophages ; Myeloid cells: ontogeny, maturation, markers, receptors ; prostaglandin E2 ; tumor necrosis factor α ; Tumor Necrosis Factor-alpha - physiology</subject><ispartof>Journal of leukocyte biology, 1993-12, Vol.54 (6), p.613-626</ispartof><rights>1993 Society for Leukocyte Biology</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4843-d9ab17534410153ec57df1efd5fedb0a7a90a364deb64b341f805ce48c0d438e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3858301$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8245715$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bonta, Ivan L</creatorcontrib><creatorcontrib>Ben-Efraim, Shlomo</creatorcontrib><title>Involvement of inflammatory mediators in macrophage antitumor activity</title><title>Journal of leukocyte biology</title><addtitle>J Leukoc Biol</addtitle><description>This review describes the potential role of macrophages in defense against cancer cells and the regulatory involvement of inflammatory mediators in this role. Interactions between macrophage‐derived cytokines (tumor necrosis factor a, interleukin‐1, IL‐6) and their interrelationships with eicosanoids (mainly the cyclooxygenase product prostaglandin E2 and some lipoxygenase metabolites) represent a network that controls the expression of antitumor activity of macrophages either in a cell‐to‐cell contact system between the effector and the target tumor cell or as cell‐free soluble products. Attention is given to the influence of tumor burden on production of cytokines and eicosanoids by macrophages and to the production of these mediators by tumor cells. Emphasis is placed on the roles of TNF‐α and PGE2 in links between inflammatory and antitumor functions of macrophages. Finally, the perspectives and still existing problems in clinical implications of macrophage‐derived cytokines are discussed in terms of a conceivable macrophage‐directed immunotherapy of cancer.</description><subject>Animals</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>antitumor activity</subject><subject>Biological and medical sciences</subject><subject>cancer immunotherapy</subject><subject>cytokines</subject><subject>cytotoxicity</subject><subject>Cytotoxicity, Immunologic</subject><subject>eicosanoids</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Humans</subject><subject>Immunobiology</subject><subject>inflammatory mediators</subject><subject>Interleukin-1 - physiology</subject><subject>Interleukin-6 - physiology</subject><subject>interleukin‐1</subject><subject>interleukin‐6</subject><subject>lipoxygenase metabolites</subject><subject>macrophages</subject><subject>Macrophages - immunology</subject><subject>Macrophages - physiology</subject><subject>Mice</subject><subject>Monocytes, macrophages</subject><subject>Myeloid cells: ontogeny, maturation, markers, receptors</subject><subject>prostaglandin E2</subject><subject>tumor necrosis factor α</subject><subject>Tumor Necrosis Factor-alpha - physiology</subject><issn>0741-5400</issn><issn>1938-3673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><recordid>eNqFkM1P2zAUwK0JxDrGbddJOcBOS_ccf8Q5AhobqBIXOFuOY1MjOyl22qj__YxS9chOfvL7va8fQt8wLDFA9evVt0tGl3zJMfmEFrghoiS8JidoATXFJaMAn9GXlF4BgFQcztCZqCirMVugu_t-N_idCaYfi8EWrrdehaDGIe6LYDr3HqX8XQSl47BZqxdTqH504zYMsVB6dDs37r-iU6t8MheH9xw93_1-uv1brh7_3N9er0pNBSVl16gW14xQigEzYjSrO4uN7Zg1XQuqVg0owmlnWk5bQrEVwLShQkNHiTDkHP2Y-27i8LY1aZTBJW28V70ZtknWHETT0Oa_IOYCV4SwDP6cwXxdStFYuYkuqLiXGOS7X5n9SkYll9lvxr8f-m7brOcIH4Tm_OUhr5JW3kbVa5eOGBFMEMAZwzM2OW_2H46UD6sbmEdfzTVr97KeXDQyBeV9XqSS0zQdV_wHu3-f8Q</recordid><startdate>199312</startdate><enddate>199312</enddate><creator>Bonta, Ivan L</creator><creator>Ben-Efraim, Shlomo</creator><general>Society for Leukocyte Biology</general><general>Federation of American Societies for Experimental Biology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>199312</creationdate><title>Involvement of inflammatory mediators in macrophage antitumor activity</title><author>Bonta, Ivan L ; Ben-Efraim, Shlomo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4843-d9ab17534410153ec57df1efd5fedb0a7a90a364deb64b341f805ce48c0d438e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>antitumor activity</topic><topic>Biological and medical sciences</topic><topic>cancer immunotherapy</topic><topic>cytokines</topic><topic>cytotoxicity</topic><topic>Cytotoxicity, Immunologic</topic><topic>eicosanoids</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Humans</topic><topic>Immunobiology</topic><topic>inflammatory mediators</topic><topic>Interleukin-1 - physiology</topic><topic>Interleukin-6 - physiology</topic><topic>interleukin‐1</topic><topic>interleukin‐6</topic><topic>lipoxygenase metabolites</topic><topic>macrophages</topic><topic>Macrophages - immunology</topic><topic>Macrophages - physiology</topic><topic>Mice</topic><topic>Monocytes, macrophages</topic><topic>Myeloid cells: ontogeny, maturation, markers, receptors</topic><topic>prostaglandin E2</topic><topic>tumor necrosis factor α</topic><topic>Tumor Necrosis Factor-alpha - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bonta, Ivan L</creatorcontrib><creatorcontrib>Ben-Efraim, Shlomo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of leukocyte biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bonta, Ivan L</au><au>Ben-Efraim, Shlomo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Involvement of inflammatory mediators in macrophage antitumor activity</atitle><jtitle>Journal of leukocyte biology</jtitle><addtitle>J Leukoc Biol</addtitle><date>1993-12</date><risdate>1993</risdate><volume>54</volume><issue>6</issue><spage>613</spage><epage>626</epage><pages>613-626</pages><issn>0741-5400</issn><eissn>1938-3673</eissn><coden>JLBIE7</coden><abstract>This review describes the potential role of macrophages in defense against cancer cells and the regulatory involvement of inflammatory mediators in this role. 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| fulltext | fulltext |
| identifier | ISSN: 0741-5400 |
| ispartof | Journal of leukocyte biology, 1993-12, Vol.54 (6), p.613-626 |
| issn | 0741-5400 1938-3673 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76089949 |
| source | Alma/SFX Local Collection |
| subjects | Animals Antineoplastic Agents - pharmacology antitumor activity Biological and medical sciences cancer immunotherapy cytokines cytotoxicity Cytotoxicity, Immunologic eicosanoids Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunobiology inflammatory mediators Interleukin-1 - physiology Interleukin-6 - physiology interleukin‐1 interleukin‐6 lipoxygenase metabolites macrophages Macrophages - immunology Macrophages - physiology Mice Monocytes, macrophages Myeloid cells: ontogeny, maturation, markers, receptors prostaglandin E2 tumor necrosis factor α Tumor Necrosis Factor-alpha - physiology |
| title | Involvement of inflammatory mediators in macrophage antitumor activity |
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