Early Abnormalities of the Antibody Response against Mycobacterium tuberculosis in Human Immunodeficiency Virus Infection

Among human immunodeficiency virus (HIV)-infected persons, those who react against purified protein derivative (PPD) have higher risk of tuberculosis. Since PPD testing has limited predictive power in HIV-positive populations, new markers of antituberculous immunity were sought by analyzing antibodi...

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Bibliographic Details
Published in:The Journal of infectious diseases 1993-12, Vol.168 (6), p.1409-1414
Main Authors: Saltini, Cesare, Amicosante, Massimo, Girardi, Enrico, Antonucci, Giorgio, Ippolito, Giuseppe, Ameglio, Franco, Monno, Laura, Congedo, Pierpaolo, Angarano, Gioacchino, Babudieri, Sergio, Guaraldi, Giovanni, Visco, Giuseppe, Piccolella, Enza, Paone, Gregorino, Pallotta, Giovanni, Bisetti, Alberto
Format: Article
Language:English
Subjects:
Adolescent
Adult
AIDS
AIDS/HIV
Antibodies
Antibodies, Bacterial - immunology
Antigens
Biological and medical sciences
Biomarkers
Blotting, Western
Enzyme linked immunosorbent assay
Female
HIV
HIV Infections - complications
HIV Infections - immunology
HIV Seropositivity - immunology
human immunodeficiency virus
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Infections
Major Articles
Male
Medical sciences
Middle Aged
Mycobacterium tuberculosis
Mycobacterium tuberculosis - immunology
Regression Analysis
T lymphocytes
Tuberculin
Tuberculin Test
Tuberculosis
Tuberculosis - complications
Tuberculosis - immunology
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Summary:Among human immunodeficiency virus (HIV)-infected persons, those who react against purified protein derivative (PPD) have higher risk of tuberculosis. Since PPD testing has limited predictive power in HIV-positive populations, new markers of antituberculous immunity were sought by analyzing antibodies to Mycobacterium tuberculosis antigens (PPD and its fraction A60) in 102 HIV-positive subjects, some PPD-positive and some PPD-negative, and in 23 HIV-positive tuberculosis patients. ELISA and Western blotting were used. Forty HIV-negative healthy subjects and 40 HIV-negative tuberculosis patients were evaluated as controls. While all those HIV-negative and PPD-positive had IgG antibodies recognizing the 38-, 28-, and 19-kDa M. tuberculosis antigens, only 26% ofthose HIV-positive and PPD-positive (all with
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/168.6.1409