Influence of meptazinol on metabolic and hormonal responses following major surgery. A comparison with morphine

Opioid drugs in high doses can obtund the stress response to major surgery but only at the expense of marked cardiorespiratory depression. The postoperative hormonal response to surgical stress was measured in 20 patients undergoing hysterectomy who were given either meptazinol 100 mg or morphine 15...

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Bibliographic Details
Published in:Anaesthesia 1985-03, Vol.40 (3), p.223-228
Main Authors: KAY, N. H, ALLEN, M. C, BULLINGHAM, r. E. S, BALDWIN, d, MCQUAY, R. J, MOORE, H. A, PRICE, R. K, SEAR, J. W
Format: Article
Language:English
Subjects:
Adult
Analgesics
Azepines - therapeutic use
Biological and medical sciences
Blood Glucose - analysis
Female
Growth Hormone - blood
Humans
Hydrocortisone - blood
Medical sciences
Meptazinol - therapeutic use
Morphine - therapeutic use
Neuropharmacology
Pharmacology. Drug treatments
Postoperative Complications - prevention & control
Prolactin - blood
Stress, Physiological - prevention & control
Thyrotropin - blood
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Summary:Opioid drugs in high doses can obtund the stress response to major surgery but only at the expense of marked cardiorespiratory depression. The postoperative hormonal response to surgical stress was measured in 20 patients undergoing hysterectomy who were given either meptazinol 100 mg or morphine 15 mg intramuscularly at the end of the surgery. Both drugs at the doses used failed to diminish the stress response. Those patients who received meptazinol showed elevated prolactin levels: this may be an indicator of agonist activity at the mu 1 opioid receptor.
ISSN:0003-2409
1365-2044
DOI:10.1111/j.1365-2044.1985.tb10746.x