Three discrete regions of deletion at 3p in head and neck cancers

Alteration of the short arm of chromosome 3 is one of the most consistent cytogenetic abnormalities found in human head and neck cancers. These alterations, composed of translocations and deletions, have been associated with the presence of a tumor suppressor gene(s), but no clear evidence of the lo...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1993-12, Vol.53 (23), p.5775-5779
Main Authors: MAESTRO, R, GASPAROTTO, D, VUKOSAVLJEVIC, T, BARZAN, L, SULFARO, S, BOIOCCHI, M
Format: Article
Language:English
Subjects:
Base Sequence
Biological and medical sciences
carcinoma
Carcinoma, Squamous Cell - genetics
chromosome 3
Chromosome Deletion
Chromosomes, Human, Pair 3
deletion
Genes, Tumor Suppressor
head and neck
Head and Neck Neoplasms - genetics
Humans
man
Medical sciences
Molecular Sequence Data
Otorhinolaryngology (head neck, general aspects and miscellaneous)
Otorhinolaryngology. Stomatology
tumor suppressor genes
Tumors
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Summary:Alteration of the short arm of chromosome 3 is one of the most consistent cytogenetic abnormalities found in human head and neck cancers. These alterations, composed of translocations and deletions, have been associated with the presence of a tumor suppressor gene(s), but no clear evidence of the location of this presumptive gene(s) was available. We performed a molecular analysis of the 3p region using a polymerase chain reaction-based approach. Twenty-eight of the 38 cases analyzed (74%) showed the presence of single or multiple areas of allelic loss. Three commonly deleted regions, tentatively mapped to 3p24-ter, 3p21.3, and 3p14--cen, were identified. Our results suggest that at least three oncosuppressor genes mapping on 3p may be involved in head and neck cancer development and support a common oncogenic pathway with squamous cell lung cancer, for which a similar pattern of 3p deletion has been described recently.
ISSN:0008-5472
1538-7445