Acute alterations in systolic ventricular interdependence-mechanical dependence of right ventricle on left ventricle following acute alteration of right ventricular free wall

The purpose of the study was to examine whether systolic ventricular interdependence can be acutely altered by changes in the mechanical properties of the ventricular wall. In eight acute canine studies, we released an aortic constriction during diastole. We measured right ventricular (RV) pressure...

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Bibliographic Details
Published in:Basic research in cardiology 1993-07, Vol.88 (4), p.350-361
Main Authors: YAMAGUCHI, S, LI, K. S, HARASAWA, H, SANTAMORE, W. P
Format: Article
Language:English
Subjects:
Animals
Aorta
Biological and medical sciences
Blood Pressure
Cardiology. Vascular system
Constriction
Coronary heart disease
Coronary Vessels
Dogs
Elasticity - drug effects
Glutaral - pharmacology
Heart
Heart - drug effects
Heart Ventricles
Medical sciences
Myocardial Ischemia - physiopathology
Systole
Venae Cavae
Ventricular Function, Left
Ventricular Function, Right
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Summary:The purpose of the study was to examine whether systolic ventricular interdependence can be acutely altered by changes in the mechanical properties of the ventricular wall. In eight acute canine studies, we released an aortic constriction during diastole. We measured right ventricular (RV) pressure changes (dPr) caused by sudden changes in left ventricular (LV) pressure (dPl). Measurements were obtained during control, 10 min after right coronary artery occlusion, and then 15 min after injecting glutaraldehyde into the RV free wall. By superimposing the pressure tracings of the beats immediately before and after the aortic release, the instantaneous pressure difference ratio (dPr/dPl) was calculated during systole. Maximal value of the pressure difference ratio decreased from control 0.11 +/- 0.04 to ischemia 0.08 +/- 0.03; (p < 0.05) and increased with glutaraldehyde 0.15 +/- 0.06; (p < 0.05). Thus, acute ischemia in RV free wall decreased the magnitude of systolic ventricular interdependence from LV to RV, while glutaraldehyde, which stiffens the RV free wall, increased the magnitude.
ISSN:0300-8428
1435-1803
DOI:10.1007/BF00800641