Is microalbuminuria part of the prediabetic state ? The Mexico City Diabetes Study

Microalbuminuria is associated with increased cardiovascular mortality in both diabetic and non-diabetic subjects. A number of studies have indicated that insulin resistance, increased blood pressure and dyslipidaemia precede the onset of clinical diabetes. We examined various correlates of microalb...

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Bibliographic Details
Published in:Diabetologia 1993-10, Vol.36 (10), p.1002-1006
Main Authors: HAFFNER, S. M, GONZALES, C, VALDEZ, R. A, MYKKÄNEN, L, HAZUDA, H. P, MITCHELL, B. D, MONTERROSA, A, STERN, M. P
Format: Article
Language:English
Subjects:
Albuminuria
Analysis of Variance
Associated diseases and complications
Biological and medical sciences
Blood Glucose - metabolism
Blood Pressure
Case-Control Studies
Cholesterol - blood
Diabetes Mellitus, Type 2 - epidemiology
Diabetes Mellitus, Type 2 - physiopathology
Diabetes Mellitus, Type 2 - urine
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Humans
Hyperlipidemias - physiopathology
Hypertension - physiopathology
Insulin Resistance
Medical sciences
Mexico - epidemiology
Middle Aged
Prediabetic State - blood
Prediabetic State - physiopathology
Prediabetic State - urine
Proteinuria
Risk Factors
Triglycerides - blood
Tropical medicine
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Summary:Microalbuminuria is associated with increased cardiovascular mortality in both diabetic and non-diabetic subjects. A number of studies have indicated that insulin resistance, increased blood pressure and dyslipidaemia precede the onset of clinical diabetes. We examined various correlates of microalbuminuria in 1,298 non-diabetic subjects who participated in the Mexico City Diabetes Study, a population-based study of diabetes and cardiovascular risk factors. Both parental history of diabetes and impaired glucose tolerance were significantly associated with microalbuminuria. These results were not explained by differences in age or blood pressure between subjects with or without a parental history of diabetes or impaired glucose tolerance. In addition, subjects with microalbuminuria had increased 2-h insulin and triglyceride concentrations, a higher prevalence of hypertension, and decreased high density lipoprotein cholesterol concentrations relative to subjects without microalbuminuria. These results that microalbuminuria may be a feature of the prediabetic state.
ISSN:0012-186X
1432-0428
DOI:10.1007/bf02374491