Regulation of sulfur and nitrogen metabolism in filamentous fungi

In the filamentous fungi, N. crassa and A. nidulans, complex regulatory circuits control nitrogen metabolism and sulfur metabolism. The expression of entire sets of unlinked structural genes that encode metabolic enzymes is repressed when favored sulfur or nitrogen sources are available. These struc...

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Bibliographic Details
Published in:Annual review of microbiology 1993, Vol.47 (1), p.31-55
Main Author: Marzluf, G.A
Format: Article
Language:English
Subjects:
Amino Acid Sequence
ASPERGILLUS NIDULANS
Aspergillus nidulans - genetics
Aspergillus nidulans - metabolism
AZOTE
AZUFRE
Biology
Fungi
Genes
Genes, Fungal
GENETIC REGULATION
GENETICA
GENETICS
GENETIQUE
METABOLISM
METABOLISME
METABOLISMO
Molecular Sequence Data
NEUROSPORA
NEUROSPORA CRASSA
Neurospora crassa - genetics
Neurospora crassa - metabolism
NITROGEN
Nitrogen - metabolism
NITROGENO
SACCHAROMYCES CEREVISIAE
SOUFRE
Sulfur
Sulfur - metabolism
SULPHUR
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Summary:In the filamentous fungi, N. crassa and A. nidulans, complex regulatory circuits control nitrogen metabolism and sulfur metabolism. The expression of entire sets of unlinked structural genes that encode metabolic enzymes is repressed when favored sulfur or nitrogen sources are available. These structural genes are coregulated by global positive-acting regulatory proteins and often are also controlled by metabolic inducers and pathway-specific regulatory proteins. The recent isolation of regulatory genes and representative structural genes of these circuits has provided significant new insight into the operation of both the nitrogen and the sulfur regulatory circuits, which involve sequence-specific DNA binding proteins, promoter control elements, metabolic inducers and repressors, and autogenous regulation.
ISSN:0066-4227
1545-3251
DOI:10.1146/annurev.mi.47.100193.000335