High susceptibility of obese hypertensive SHRSP.Z-Lepr(fa) /IzmDmcr rats to lipid deposition in the mesenteric artery

1. Atherosclerosis is commonly observed in obesity. Obese atherosclerosis-prone animals may be a promising tool for understanding the pathophysiology of obesity-associated atherosclerosis. However, most rat strains are resistant to atherosclerosis. The aim of the present study was to assess the susc...

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Published in:Clinical and experimental pharmacology & physiology 2010-11, Vol.37 (11), p.1102-1104
Main Authors: Kunimasa, Kazuhiro, Yoshitomi, Hisae, Miura, Chitose, Mori, Hideki, Tsuchikura, Satoru, Ikeda, Katsumi, Gao, Ming, Yamori, Yukio, Mori, Mari
Format: Article
Language:English
Subjects:
Animals
Atherosclerosis - etiology
Atherosclerosis - metabolism
Body Weight
Disease Models, Animal
Hypertension - complications
Hypertension - metabolism
Lipid Metabolism
Lipids - blood
Male
Mesenteric Arteries - metabolism
Obesity - complications
Obesity - metabolism
Rats
Rats, Inbred Strains
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Summary:1. Atherosclerosis is commonly observed in obesity. Obese atherosclerosis-prone animals may be a promising tool for understanding the pathophysiology of obesity-associated atherosclerosis. However, most rat strains are resistant to atherosclerosis. The aim of the present study was to assess the susceptibility of two obese hypertensive rat models, namely SHRSP.Z-Lepr(fa) /IzmDmcr rats (SHRSP-fatty) and SHR.Cg-Lepr(cp) /NDmcr rats (SHR-cp), to arterial lipid deposition, an initial stage of atherosclerosis, by comparing these strains with non-obese stroke-prone spontaneously hypertensive rats (SHRSP). 2. Eight-week-old male SHRSP, SHRSP-fatty and SHR-cp were fed a high-fat and high-cholesterol diet containing 20% palm oil, 5% cholesterol and 2% cholic acid for 5weeks. Bodyweight, blood pressure and fasting serum levels of total cholesterol and triglycerides were measured in 12-week-old rats. Oil red O staining was used to visualize lipid deposition in the mesenteric artery. 3. The bodyweight of 12-week-old SHRSP-fatty and SHR-cp was higher than that of SHRSP (P
ISSN:1440-1681
DOI:10.1111/j.1440-1681.2010.05440.x