Synthetic studies on the mycolactone core

Two approaches are presented for the synthesis of the macrolide core of the mycolactone polyketides. The first intertwines ring closing metathesis (RCM) within a two-step Julia olefination protocol, while the second intercepts the optimized routes of Kishi, thereby providing formal access to the myc...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2010-11, Vol.8 (22), p.5159-5165
Main Authors: Ko, Kwang-Seuk, Alexander, Matthew D, Fontaine, Shaun D, Biggs-Houck, James E, La Clair, James J, Burkart, Michael D
Format: Article
Language:English
Subjects:
Alkenes
Bacterial Toxins - chemical synthesis
Bacterial Toxins - chemistry
Macrolides
Mycobacterium - chemistry
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Summary:Two approaches are presented for the synthesis of the macrolide core of the mycolactone polyketides. The first intertwines ring closing metathesis (RCM) within a two-step Julia olefination protocol, while the second intercepts the optimized routes of Kishi, thereby providing formal access to the mycolactones.
ISSN:1477-0520
1477-0539
DOI:10.1039/c0ob00540a