Lecithinized superoxide dismutase treatment improves steroid‐refractory interstitial pneumonia

ABSTRACT Pulmonary fibrosis associated with amyopathic dermatomyositis is known to have a generally aggressive course and is ultimately fatal. We report the case of a 50‐year‐old patient with amyopathic dermatomyositis, who developed progressive interstitial pneumonia that was unresponsive to cortic...

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Bibliographic Details
Published in:Respirology (Carlton, Vic.) Vic.), 2010-11, Vol.15 (8), p.1261-1265
Main Authors: KAWASHIMA, Tatsuo, WAKABAYASHI, Toru, KURODA, Toshihisa, NISHIDE, Toshio, MATSUZAWA, Yasuo, SHIRAI, Kohji
Format: Article
Language:English
Subjects:
Adrenal Cortex Hormones - therapeutic use
amyopathic dermatomyositis
Cyclosporine - therapeutic use
Dermatomyositis - drug therapy
Exercise Tolerance - drug effects
Humans
Immunosuppressive Agents - therapeutic use
interstitial pneumonia
Lung Diseases, Interstitial - diagnostic imaging
Lung Diseases, Interstitial - drug therapy
Male
Methylprednisolone - therapeutic use
Middle Aged
Mucin-1 - blood
Phosphatidylcholines - adverse effects
Phosphatidylcholines - therapeutic use
Prednisolone - therapeutic use
Pulmonary Fibrosis - diagnostic imaging
Pulmonary Fibrosis - drug therapy
Radiography
Respiratory Function Tests
steroid‐refractory
superoxide
superoxide dismutase
Superoxide Dismutase - adverse effects
Superoxide Dismutase - therapeutic use
Tacrolimus - therapeutic use
Treatment Outcome
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Summary:ABSTRACT Pulmonary fibrosis associated with amyopathic dermatomyositis is known to have a generally aggressive course and is ultimately fatal. We report the case of a 50‐year‐old patient with amyopathic dermatomyositis, who developed progressive interstitial pneumonia that was unresponsive to corticosteroids and multiple immunosuppressive agents, including cyclosporine and tacrolimus hydrate. Five courses of lecithinized superoxide dismutase were administered without adverse effects. Improvements in physiological parameters, such as pulmonary function and exercise tolerance, as well as the serum Krebs von den Lungen 6 level, were observed. This is the first report of a case of steroid‐refractory interstitial pneumonia treated with lecithinized superoxide dismutase.
ISSN:1323-7799
1440-1843
DOI:10.1111/j.1440-1843.2010.01851.x