Analysis of the Qa-4 allodeterminant

Several Qa/Tla region-encoded antigens have demonstrated an interesting relationship to Qa-2, Qa-3, 4, 5, 6, m7, m8, m9, and m208 are only detected in mouse strains which also express Qa-2, suggesting that the Qa-2 molecule may play a pivotal role in the expression of these eight cell-surface determ...

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Bibliographic Details
Published in:Immunogenetics (New York) 1985-01, Vol.21 (5), p.511-516
Main Authors: Landolfi, N F, Rich, R R, Bevan, M J, Cook, R G
Format: Article
Language:English
Subjects:
Animals
Antibodies, Monoclonal - immunology
Antigens, Surface - immunology
Binding, Competitive
Epitopes - immunology
Histocompatibility Antigens Class I
Hybridomas - immunology
Lymphocyte Activation
Mice
Mice, Inbred Strains
Species Specificity
T-Lymphocytes - immunology
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Summary:Several Qa/Tla region-encoded antigens have demonstrated an interesting relationship to Qa-2, Qa-3, 4, 5, 6, m7, m8, m9, and m208 are only detected in mouse strains which also express Qa-2, suggesting that the Qa-2 molecule may play a pivotal role in the expression of these eight cell-surface determinants. There is a particularly close correlation between Qa-2 and Qa-4, which have an identical mouse strain distribution and differ only in tissue expression; Qa-2 is detectable on thymocytes (Flaherty 1976), while Qa-4 is not. The authors have generated and characterized a monoclonal antibody (mAb) with specificity for the Qa-4 allodeterminant, and used it to examine the relationship between Qa-2 and Qa-4.
ISSN:0093-7711
1432-1211
DOI:10.1007/BF00430934