Inhibition of growth of leukemic cells by inhibitors of calmodulin: phenothiazines and melittin

Calmodulin, a ubiquitous calcium-binding protein, has recently been shown to play an important role in cellular proliferation. The calmodulin inhibitors melittin, trifluoperazine, and chlorpromazine inhibited the growth and clonogenicity of human and murine leukemic cells, and their potency reflecte...

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Bibliographic Details
Published in:Cancer chemotherapy and pharmacology 1985-01, Vol.14 (3), p.202-205
Main Authors: HAIT, W. N, GRAIS, L, BENZ, C, CADMAN, E. C
Format: Article
Language:English
Subjects:
Animals
Antineoplastic agents
Bee Venoms - pharmacology
Biological and medical sciences
Calmodulin - antagonists & inhibitors
Cell Division - drug effects
General aspects
Humans
Leukemia - drug therapy
Leukemia - pathology
Medical sciences
Melitten - pharmacology
Mice
Pharmacology. Drug treatments
Phenothiazines - pharmacology
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Summary:Calmodulin, a ubiquitous calcium-binding protein, has recently been shown to play an important role in cellular proliferation. The calmodulin inhibitors melittin, trifluoperazine, and chlorpromazine inhibited the growth and clonogenicity of human and murine leukemic cells, and their potency reflected their activity as inhibitors of calmodulin. Melittin, which is a far more potent inhibitor of calmodulin activity, was also a more potent inhibitor of cell growth and clonogenicity. The less active phenothiazine metabolite, chlorpromazine sulfoxide, had much less potent cytotoxic activity.
ISSN:0344-5704
1432-0843
DOI:10.1007/BF00258116