Effect of hydroxypropyl-β-cyclodextrin on efficacy of oral itraconazole in disseminated murine cryptococcosis

The therapeutic efficacy of itraconazole solubilized in either the commonly used vehicle, polyethylene-glycol-200 (PEG) or hydroxypropyl β-cyclodextrin was compared in a murine model of disseminated cryptococcosis. Itraconazole at doses of up to 120 mg/kg/day solubilized in PEG were found not to be...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1993-09, Vol.32 (3), p.459-463
Main Authors: Hostetler, John S., Hanson, Linda H., Stevens, David A.
Format: Article
Language:English
Subjects:
2-Hydroxypropyl-beta-cyclodextrin
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal agents
beta-Cyclodextrins
Biological and medical sciences
Cryptococcosis - drug therapy
Cryptococcosis - microbiology
Cyclodextrins - pharmacology
Excipients
Female
Itraconazole - administration & dosage
Itraconazole - pharmacology
Medical sciences
Mice
Pharmacology. Drug treatments
Polyethylene Glycols
Solutions
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Description
Summary:The therapeutic efficacy of itraconazole solubilized in either the commonly used vehicle, polyethylene-glycol-200 (PEG) or hydroxypropyl β-cyclodextrin was compared in a murine model of disseminated cryptococcosis. Itraconazole at doses of up to 120 mg/kg/day solubilized in PEG were found not to be effective. However, itraconazole at doses ≥ 30 mg/kg/day solubilized in hydroxypropyl-β-cyclodextrin markedly prolonged survival and a relationship between dose and survival was seen.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/32.3.459