Metrizamide myelography in patients with small cell carcinoma of the lung suspected of meningeal carcinomatosis

Twenty patients suspected of meningeal carcinomatosis (MC) secondary to small cell carcinoma of the lung were evaluated by myelography and by cytologic examination of cerebrospinal fluid (CSF). In 4 patients both investigations demonstrated MC. Four had positive cytology but a negative myelogram. Fi...

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Bibliographic Details
Published in:Journal of neuro-oncology 1985-01, Vol.3 (1), p.85-89
Main Authors: Pedersen, A G, Paulson, O B, Gyldensted, C
Format: Article
Language:English
Subjects:
Carcinoma, Small Cell - diagnostic imaging
Carcinoma, Small Cell - secondary
Diagnosis, Differential
Humans
Lung Neoplasms - diagnostic imaging
Meningeal Neoplasms - diagnostic imaging
Meningeal Neoplasms - secondary
Metrizamide
Myelography
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Summary:Twenty patients suspected of meningeal carcinomatosis (MC) secondary to small cell carcinoma of the lung were evaluated by myelography and by cytologic examination of cerebrospinal fluid (CSF). In 4 patients both investigations demonstrated MC. Four had positive cytology but a negative myelogram. Five patients had a positive myelogram but negative cytology. Thus 13 of the 20 patients had MC diagnosed by one or both of these investigations. Two additional patients suspected of MC were studied; both had positive myelography, but cytologic examination of CSF was not performed in either case. Six patients underwent autopsy with microscopic examination of the spinal cord; in all cases post-mortem findings supported myelographic findings. In conclusion, myelography is useful in the evaluation of patients suspected of MC secondary to small carcinoma of the lung and complements the diagnostic role of CSF examination.
ISSN:0167-594X
1573-7373
DOI:10.1007/BF00165176