The induction of specific immunity against Schistosoma japonicum by exposure of mice to ultraviolet attenuated cercariae

Mice can be partially protected against Schistosoma japonicum by prior exposure to ultraviolet (UV)-attenuated infections which fail to survive to the adult stage and produce no overt pathology in the host. Optimum resistance was induced by parasites exposed to 40 seconds of UV, significantly lower...

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Bibliographic Details
Published in:Parasitology 1985-04, Vol.90 (2), p.313-323
Main Authors: Moloney, N. A., Bickle, Q. D., Webbe, G.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Diseases caused by trematodes
Female
Fundamental and applied biological sciences. Psychology
Helminthic diseases
Infectious diseases
Invertebrates
Medical sciences
Mice
Mice, Inbred CBA
Nemathelminthia. Plathelmintha
Parasitic diseases
Physiology. Development
schistosoma japonicum
Schistosoma japonicum - immunology
Schistosoma japonicum - radiation effects
Schistosomiases
Schistosomiasis - immunology
Schistosomiasis - prevention & control
Tropical medicine
Ultraviolet Rays
Vaccination
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Summary:Mice can be partially protected against Schistosoma japonicum by prior exposure to ultraviolet (UV)-attenuated infections which fail to survive to the adult stage and produce no overt pathology in the host. Optimum resistance was induced by parasites exposed to 40 seconds of UV, significantly lower levels of resistance being stimulated by both shorter and longer exposures. No consistent relationship between the degree of resistance induced and the number of irradiated cercariae given could be demonstrated and equivocal results were obtained when comparing the efficacy of single and multiple vaccinations. Vaccinations with UV-attenuated cercariae given intraperitoneally (i.p.) were as efficacious as those given percutaneously but mice were as or more resistant to challenges given by the i.p. route, the possible reasons are discussed. There was no observed delay in the migration of the challenge, vaccinated mice being as resistant when perfused 6 or 3·5 weeks after challenge. Vaccination was species specific since mice exposed to either UV-attenuated S. japonicum cercariae or gamma-attenuated S. mansoni cercariae were resistant to homologous but not heterologous challenge.
ISSN:0031-1820
1469-8161
DOI:10.1017/S0031182000051015