Persistence of Vaccine-Induced Immune Responses to Rubella: Comparison with Natural Infection

Serologic responses and patterns of antibody persistence in children given HPV-77 DE-5 or RA27/3 vaccine were compared with those in children who had experienced natural infection. The results indicated that both vaccines induce long-lasting immunity in most individuals. RA27/3 vaccine proved more i...

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Bibliographic Details
Published in:Reviews of infectious diseases 1985-03, Vol.7, p.S80-S85
Main Authors: Horstmann, Dorothy M., Schluederberg, Ann, Jean E. Emmons, Brigitte K. Evans, Martin F. Randolph, Andiman, Warren A.
Format: Article
Language:English
Subjects:
Antibodies
Antibodies, Viral - analysis
Child
Child, Preschool
Children
Enzyme linked immunosorbent assay
Follow-Up Studies
Hemagglutination Inhibition Tests
Humans
Immunity
Immunization
Infant
Infections
Latex Fixation Tests
Neutralization Tests
Rubella
Rubella - immunology
Rubella - prevention & control
Rubella Vaccine - immunology
Rubella virus
Rubella virus - immunology
Session III: Rubella Vaccines
Vaccination
Viruses
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Summary:Serologic responses and patterns of antibody persistence in children given HPV-77 DE-5 or RA27/3 vaccine were compared with those in children who had experienced natural infection. The results indicated that both vaccines induce long-lasting immunity in most individuals. RA27/3 vaccine proved more immunogenic and resulted in higher antibody titers; after 11 years 95% of those who seroconverted who were tested had hemagglutination-inhibiting (HAI) antibodies and 100% had neutralizing (NT) antibodies. Titers in HPV-77 DE-5 vaccines were lower, and in 16% of those whose immune responses were feeble, HAI titers decreased to
ISSN:0162-0886