ANTHRACYCLINE METABOLITES FROM BAUMYCIN-PRODUCING Streptomyces sp. D788: III. NEW ANTHRACYCLINE METABOLITES PRODUCED BY BLOCKED MUTANTS 4L-660 AND YDK-18

In a previous paper, we described isolation of a variety of blocked mutants from baumycin-producing Streptomyces sp. D788 and identification of the biosynthetically blocked anthracycline metabolites produced by some of them. This paper deals with details of the anthracyclines produced by another two...

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Bibliographic Details
Published in:Journal of antibiotics 1993/11/25, Vol.46(11), pp.1758-1761
Main Authors: YOSHIMOTO, AKIHIRO, JOHDO, OSAMU, NISHIDA, HIROSHI, OKAMOTO, ROKURO, TAKEUCHI, TOMIO
Format: Article
Language:English
Subjects:
Animals
Antibacterial agents
Antibiotics, Antineoplastic - chemistry
Antibiotics, Antineoplastic - isolation & purification
Antibiotics, Antineoplastic - pharmacology
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Daunorubicin - analogs & derivatives
Leukemia L1210 - drug therapy
Medical sciences
Mice
Pharmacology. Drug treatments
Streptomyces
Streptomycin - chemistry
Tumor Cells, Cultured - drug effects
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Summary:In a previous paper, we described isolation of a variety of blocked mutants from baumycin-producing Streptomyces sp. D788 and identification of the biosynthetically blocked anthracycline metabolites produced by some of them. This paper deals with details of the anthracyclines produced by another two blocked mutants, strains 4L-660 and YDK-18.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.46.1758