IC101, EXTRACELLULAR MATRIX ANTAGONIST PRODUCED BY Streptomyces sp. MJ202-72F3: PRODUCTION, ISOLATION, STRUCTURE DETERMINATION AND BIOLOGICAL ACTIVITY

In our search for inhibitors of cell adhesion to components of extracellular matrix (ECM), fibronectin, laminin and collagen type IV, we succeeded in finding a novel cyclic hexadepsipeptide antibiotic, named IC101, which was isolated from cultured mycelium of Streptomyces albulus MJ202-72F3. It was...

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Bibliographic Details
Published in:Journal of antibiotics 1993/11/25, Vol.46(11), pp.1658-1665
Main Authors: UENO, MITSUHIRO, AMEMIYA, MASAHIDE, SOMENO, TETSUYA, MASUDA, TORU, IINUMA, HIRONOBU, NAGANAWA, HIROSHI, HAMADA, MASA, ISHIZUKA, MASAAKI, TAKEUCHI, TOMIO
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Antibody Formation - drug effects
Antineoplastic agents
Biological and medical sciences
Extracellular Matrix Proteins - drug effects
Female
General aspects
Leukemia P388 - drug therapy
Medical sciences
Mice
Mice, Inbred ICR
Microbial Sensitivity Tests
Peptides
Peptides, Cyclic - chemistry
Peptides, Cyclic - isolation & purification
Peptides, Cyclic - pharmacology
Pharmacology. Drug treatments
Rats
Rats, Inbred F344
Streptomyces - chemistry
Streptomyces albulus
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Summary:In our search for inhibitors of cell adhesion to components of extracellular matrix (ECM), fibronectin, laminin and collagen type IV, we succeeded in finding a novel cyclic hexadepsipeptide antibiotic, named IC101, which was isolated from cultured mycelium of Streptomyces albulus MJ202-72F3. It was purified by centrifugal partition chromatography, preparative reverse phase HPLC and Sephadex LH-20 and was obtained as a white powder. 1C 101 strongly inhibited cell adhesion to ECM components, suppressed immune responses in vitro and in vivo, and exhibited antimicrobial activity on Gram-positive bacteria.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.46.1658