Interactions of dicarboxylic porphyrins with membranes in relation to their ionization state

The interactions of dicarboxylic porphyrins with membrane systems are discussed with particular emphasis on the effect of the charge of the porphyrin and the nature of the side-chains. The incorporation of hematoporphyrin or related dicarboxylic porphyrins within small unilamellar vesicles as membra...

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Bibliographic Details
Published in:Journal of photochemistry and photobiology. B, Biology Biology, 1993-10, Vol.20 (2), p.191-195
Main Authors: Brault, D., Vever-Bizet, C., Kuzelova, K.
Format: Article
Language:English
Subjects:
Animals
Artificial membranes and reconstituted systems
Biological and medical sciences
Carboxylic Acids - chemistry
Fluorescence
Fundamental and applied biological sciences. Psychology
Hematoporphyrins - chemistry
Ionization
Ions
Kinetics
Membrane models
Membrane physicochemistry
Membranes - chemistry
Membranes, Artificial
Molecular biophysics
Partition
Photodynamic therapy
Porphyrins
Porphyrins - chemistry
Small unilamellar vesicles
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Summary:The interactions of dicarboxylic porphyrins with membrane systems are discussed with particular emphasis on the effect of the charge of the porphyrin and the nature of the side-chains. The incorporation of hematoporphyrin or related dicarboxylic porphyrins within small unilamellar vesicles as membrane models is favored by a decrease of the pH in the range of physiological pH values. This effect might play an important role in the retention of porphyrins by tumors, which are more acidic than normal tissues. Kinetics studies also show that the partition of the porphyrin between the lipidic bilayer and the aqueous phase is governed by its release rate rather than by its incorporation rate.
ISSN:1011-1344
1873-2682
DOI:10.1016/1011-1344(93)80150-8