Clonidine produces a conditioned place preference in rats

The possibility that the alpha-adrenergic agonist clonidine can act as a reinforcing agent was investigated using the conditioned place preference paradigm. Using two different variants of this method we were able to demonstrate reinforcing properties of clonidine at doses of 200 and 400 micrograms/...

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Bibliographic Details
Published in:Psychopharmacologia 1985-01, Vol.85 (3), p.383-385
Main Authors: ASIN, K. E, WIRTSHAFTER, D
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Catecholaminergic system
Clonidine - pharmacology
Conditioning, Operant - drug effects
Male
Medical sciences
Neuropharmacology
Neurotransmitters. Neurotransmission. Receptors
Pharmacology. Drug treatments
Rats
Rats, Inbred Strains
Reinforcement (Psychology)
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Summary:The possibility that the alpha-adrenergic agonist clonidine can act as a reinforcing agent was investigated using the conditioned place preference paradigm. Using two different variants of this method we were able to demonstrate reinforcing properties of clonidine at doses of 200 and 400 micrograms/kg. These results are consistent with those obtained by other investigators using the self-administration technique, and support the view that adrenergic mechanisms may be involved in reinforcement.
ISSN:0033-3158
1432-2072
DOI:10.1007/BF00428206