Effects of Semotiadil Fumarate, a Novel Calcium Antagonist, on Blood Pressure and Heart Rate in Conscious Spontaneously Hypertensive Rats

The acute antihypertensive effects of orally administered semotiadil, a novel calcium antagonist, were compared with those of nifedipine and diltiazem in conscious, unrestrained spontaneously hypertensive rats (SHRs). Semotiadil (10 and 30 mg/kg) produced a dose-dependent hypotension that persisted...

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Bibliographic Details
Published in:Japanese Journal of Pharmacology 1993, Vol.63(1), pp.121-124
Main Authors: Kanda, Akira, Hashimoto, Hiroo
Format: Article
Language:English
Subjects:
Animals
Antihypertensive agents
Antihypertensive effect
Biological and medical sciences
Blood Pressure - drug effects
Calcium Channel Blockers - pharmacology
Calcium Channel Blockers - therapeutic use
Cardiovascular system
Diltiazem - pharmacology
Dose-Response Relationship, Drug
Heart Rate - drug effects
Hypertension - drug therapy
Hypertension - physiopathology
Male
Medical sciences
Nifedipine - pharmacology
Pharmacology. Drug treatments
Rats
Rats, Inbred SHR
Semotiadil
Spontaneously hypertensive rat
Thiazoles - pharmacology
Thiazoles - therapeutic use
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Summary:The acute antihypertensive effects of orally administered semotiadil, a novel calcium antagonist, were compared with those of nifedipine and diltiazem in conscious, unrestrained spontaneously hypertensive rats (SHRs). Semotiadil (10 and 30 mg/kg) produced a dose-dependent hypotension that persisted for 18 hr at 30 mg/kg. Diltiazem (30 and 100 mg/kg) and nifedipine (1 and 3 mg/kg) also exhibited hypotension dose-dependently, but their durations of actions were shorter than that of semotiadil. Semotiadil caused a slight increase in heart rate, while diltiazem and nifedipine caused a bradycardia and a marked tachycardia, respectively. These results suggest that semotiadil has a beneficial property as an anti-hypertensive drug.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.63.121