Biotechnology and bone graft substitutes

Trauma, disease, developmental deformities, and tumor resection frequently cause bone defects that seriously challenge the skills of orthopedic and maxillofacial surgeons. Currently, repairing osseous deficiencies involves various medical surgical techniques, including autogenous grafts, allografts,...

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Bibliographic Details
Published in:Pharmaceutical research 1993-10, Vol.10 (10), p.1393-1401
Main Authors: KENLEY, R. A, YIM, K, ABRAMS, J, RON, E, TUREK, T, MARDEN, L. J, HOLLINGER, J. O
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Biological and medical sciences
Biotechnology
Bone and Bones - drug effects
Bone and Bones - physiology
Bone Morphogenetic Proteins
Bone Regeneration
Bone Transplantation
Growth Substances - administration & dosage
Growth Substances - therapeutic use
Humans
Medical sciences
Molecular Sequence Data
Orthopedic surgery
Orthopedics
Proteins - chemistry
Proteins - pharmacology
Proteins - therapeutic use
Rats
Recombinant Proteins - pharmacology
Recombinant Proteins - therapeutic use
Regeneration
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
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Summary:Trauma, disease, developmental deformities, and tumor resection frequently cause bone defects that seriously challenge the skills of orthopedic and maxillofacial surgeons. Currently, repairing osseous deficiencies involves various medical surgical techniques, including autogenous grafts, allografts, internal and external fixation devices, electrical stimulation, and alloplastic implants. The existing technology, though effective in many cases, still is beset with numerous difficulties and disadvantages. A critical need for improved treatment methods exists today. Biotechnology now provides access to new bone repair concepts via administration of protein growth and morphogenic factors. Implantable device and drug delivery system technologies also have advanced. The converging biopharmaceutical, device, and delivery technologies represent an opportunity to improve the quality of health care for individuals with orthopedic and maxillofacial deficiencies. This report reviews current concepts in fracture healing and bone repair and examines existing treatment modalities. It also addresses novel protein drugs that stimulate osseous regeneration and delivery systems for these drugs.
ISSN:0724-8741
1573-904X
DOI:10.1023/A:1018902720816