Loading…
The Mosaic Genome of Warm-Blooded Vertebrates
Most of the nuclear genome of warm-blooded vertebrates is a mosaic of very long (>>200 kilobases) DNA segments, the isochores; these isochores are fairly homogeneous in base composition and belong to a small number of major classes distinguished by differences in guanine-cytosine (GC) content....
Saved in:
| Published in: | Science (American Association for the Advancement of Science) 1985-05, Vol.228 (4702), p.953-958 |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c706t-71799fefca62791089a8fb129639a9a9084d88426b2065cda5d9b75dbd9ece0a3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c706t-71799fefca62791089a8fb129639a9a9084d88426b2065cda5d9b75dbd9ece0a3 |
| container_end_page | 958 |
| container_issue | 4702 |
| container_start_page | 953 |
| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 228 |
| creator | Bernardi, Giorgio Olofsson, Birgitta Filipski, Jan Zerial, Marino Salinas, Julio Cuny, Gerard Meunier-Rotival, Michele Rodier, Francis |
| description | Most of the nuclear genome of warm-blooded vertebrates is a mosaic of very long (>>200 kilobases) DNA segments, the isochores; these isochores are fairly homogeneous in base composition and belong to a small number of major classes distinguished by differences in guanine-cytosine (GC) content. The families of DNA molecules derived from such classes can be separated and used to study the genome distribution of any sequence which can be probed. This approach has revealed (i) that the distribution of genes, integrated viral sequences, and interspersed repeats is highly nonuniform in the genome, and (ii) that the base composition and ratio of CpG to GpC in both coding and noncoding sequences, as well as codon usage, mainly depend on the GC content of the isochores harboring the sequences. The compositional compartmentalization of the genome of warm-blooded vertebrates is discussed with respect to its evolutionary origin, its causes, and its effects on chromosome structure and function. |
| doi_str_mv | 10.1126/science.4001930 |
| format | article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_76145885</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A3783782</galeid><jstor_id>1694234</jstor_id><sourcerecordid>A3783782</sourcerecordid><originalsourceid>FETCH-LOGICAL-c706t-71799fefca62791089a8fb129639a9a9084d88426b2065cda5d9b75dbd9ece0a3</originalsourceid><addsrcrecordid>eNqN0s9rFDEUB_AgSl2rZy8KcxA91GnzazLJsV10LazuwVqP4U3mzTplZtIms2D_-6bs0FZYcHmBQL6fJIf3CHnL6DFjXJ1E1-Lg8FhSyoygz8iMUVPkhlPxnMwoFSrXtCxeklcxXlGaMiMOyMHEZyS_-IPZdx-hddkCB99j5pvsN4Q-P-u8r7HOLjGMWAUYMb4mLxroIr6Z9kPy6-uXi_m3fLlanM9Pl7krqRrzkpXGNNg4ULw0jGoDuqkYN0oYSEW1rLWWXFWcqsLVUNSmKou6qg06pCAOycftu9fB32wwjrZvo8OugwH9JtpSMVloXfwXMikKLst7eLSFa-jQtkPjxwBujQMG6PyATZuOT0Wp0-JJf96hU9XYt24H__QPT2LEv-MaNjHa858_9pWry33l2WJPqRfLp_Jol3S-63CNNrVwvnqqT7baBR9jwMZeh7aHcGsZtffDZ6fhs9M0pRvvp25sqh7rB_-Yf5hyiA66JsDg2vjADONMapHYuy27iqMPj78qI7mQ4g5nF-Y6</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>14352475</pqid></control><display><type>article</type><title>The Mosaic Genome of Warm-Blooded Vertebrates</title><source>American Association for the Advancement of Science</source><source>JSTOR Archival Journals and Primary Sources Collection</source><creator>Bernardi, Giorgio ; Olofsson, Birgitta ; Filipski, Jan ; Zerial, Marino ; Salinas, Julio ; Cuny, Gerard ; Meunier-Rotival, Michele ; Rodier, Francis</creator><creatorcontrib>Bernardi, Giorgio ; Olofsson, Birgitta ; Filipski, Jan ; Zerial, Marino ; Salinas, Julio ; Cuny, Gerard ; Meunier-Rotival, Michele ; Rodier, Francis</creatorcontrib><description>Most of the nuclear genome of warm-blooded vertebrates is a mosaic of very long (>>200 kilobases) DNA segments, the isochores; these isochores are fairly homogeneous in base composition and belong to a small number of major classes distinguished by differences in guanine-cytosine (GC) content. The families of DNA molecules derived from such classes can be separated and used to study the genome distribution of any sequence which can be probed. This approach has revealed (i) that the distribution of genes, integrated viral sequences, and interspersed repeats is highly nonuniform in the genome, and (ii) that the base composition and ratio of CpG to GpC in both coding and noncoding sequences, as well as codon usage, mainly depend on the GC content of the isochores harboring the sequences. The compositional compartmentalization of the genome of warm-blooded vertebrates is discussed with respect to its evolutionary origin, its causes, and its effects on chromosome structure and function.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.4001930</identifier><identifier>PMID: 4001930</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: The American Association for the Advancement of Science</publisher><subject>Animals ; Base Composition ; Base Sequence ; Biochemistry ; Biological and medical sciences ; Biological Evolution ; Centrifugation, Density Gradient ; Chickens ; Chickens - genetics ; Chromosome Banding ; Chromosomes ; Codon ; Codons ; Cytosine - analysis ; DNA - analysis ; DNA - genetics ; DNA Replication ; DNA, Viral - genetics ; Evolution ; Evolution (Biology) ; Exons ; Fundamental and applied biological sciences. Psychology ; Gene Amplification ; Genes ; Genes, Viral ; Genes. Genome ; Genetic aspects ; Genomes ; Globular star clusters ; Guanine - analysis ; Humans ; Introns ; Isochores ; Mammals - genetics ; Mice - genetics ; Molecular and cellular biology ; Molecular genetics ; Mutation ; Nucleic acids ; Rabbits - genetics ; Recombination, Genetic ; Repetitive Sequences, Nucleic Acid ; Vertebrata ; Vertebrates ; Xenopus - genetics</subject><ispartof>Science (American Association for the Advancement of Science), 1985-05, Vol.228 (4702), p.953-958</ispartof><rights>Copyright 1985 The American Association for the Advancement of Science</rights><rights>1985 INIST-CNRS</rights><rights>COPYRIGHT 1985 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1985 American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c706t-71799fefca62791089a8fb129639a9a9084d88426b2065cda5d9b75dbd9ece0a3</citedby><cites>FETCH-LOGICAL-c706t-71799fefca62791089a8fb129639a9a9084d88426b2065cda5d9b75dbd9ece0a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1694234$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1694234$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,777,781,2871,2872,27905,27906,58219,58452</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9121483$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4001930$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bernardi, Giorgio</creatorcontrib><creatorcontrib>Olofsson, Birgitta</creatorcontrib><creatorcontrib>Filipski, Jan</creatorcontrib><creatorcontrib>Zerial, Marino</creatorcontrib><creatorcontrib>Salinas, Julio</creatorcontrib><creatorcontrib>Cuny, Gerard</creatorcontrib><creatorcontrib>Meunier-Rotival, Michele</creatorcontrib><creatorcontrib>Rodier, Francis</creatorcontrib><title>The Mosaic Genome of Warm-Blooded Vertebrates</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Most of the nuclear genome of warm-blooded vertebrates is a mosaic of very long (>>200 kilobases) DNA segments, the isochores; these isochores are fairly homogeneous in base composition and belong to a small number of major classes distinguished by differences in guanine-cytosine (GC) content. The families of DNA molecules derived from such classes can be separated and used to study the genome distribution of any sequence which can be probed. This approach has revealed (i) that the distribution of genes, integrated viral sequences, and interspersed repeats is highly nonuniform in the genome, and (ii) that the base composition and ratio of CpG to GpC in both coding and noncoding sequences, as well as codon usage, mainly depend on the GC content of the isochores harboring the sequences. The compositional compartmentalization of the genome of warm-blooded vertebrates is discussed with respect to its evolutionary origin, its causes, and its effects on chromosome structure and function.</description><subject>Animals</subject><subject>Base Composition</subject><subject>Base Sequence</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Biological Evolution</subject><subject>Centrifugation, Density Gradient</subject><subject>Chickens</subject><subject>Chickens - genetics</subject><subject>Chromosome Banding</subject><subject>Chromosomes</subject><subject>Codon</subject><subject>Codons</subject><subject>Cytosine - analysis</subject><subject>DNA - analysis</subject><subject>DNA - genetics</subject><subject>DNA Replication</subject><subject>DNA, Viral - genetics</subject><subject>Evolution</subject><subject>Evolution (Biology)</subject><subject>Exons</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Amplification</subject><subject>Genes</subject><subject>Genes, Viral</subject><subject>Genes. Genome</subject><subject>Genetic aspects</subject><subject>Genomes</subject><subject>Globular star clusters</subject><subject>Guanine - analysis</subject><subject>Humans</subject><subject>Introns</subject><subject>Isochores</subject><subject>Mammals - genetics</subject><subject>Mice - genetics</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Mutation</subject><subject>Nucleic acids</subject><subject>Rabbits - genetics</subject><subject>Recombination, Genetic</subject><subject>Repetitive Sequences, Nucleic Acid</subject><subject>Vertebrata</subject><subject>Vertebrates</subject><subject>Xenopus - genetics</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><recordid>eNqN0s9rFDEUB_AgSl2rZy8KcxA91GnzazLJsV10LazuwVqP4U3mzTplZtIms2D_-6bs0FZYcHmBQL6fJIf3CHnL6DFjXJ1E1-Lg8FhSyoygz8iMUVPkhlPxnMwoFSrXtCxeklcxXlGaMiMOyMHEZyS_-IPZdx-hddkCB99j5pvsN4Q-P-u8r7HOLjGMWAUYMb4mLxroIr6Z9kPy6-uXi_m3fLlanM9Pl7krqRrzkpXGNNg4ULw0jGoDuqkYN0oYSEW1rLWWXFWcqsLVUNSmKou6qg06pCAOycftu9fB32wwjrZvo8OugwH9JtpSMVloXfwXMikKLst7eLSFa-jQtkPjxwBujQMG6PyATZuOT0Wp0-JJf96hU9XYt24H__QPT2LEv-MaNjHa858_9pWry33l2WJPqRfLp_Jol3S-63CNNrVwvnqqT7baBR9jwMZeh7aHcGsZtffDZ6fhs9M0pRvvp25sqh7rB_-Yf5hyiA66JsDg2vjADONMapHYuy27iqMPj78qI7mQ4g5nF-Y6</recordid><startdate>19850524</startdate><enddate>19850524</enddate><creator>Bernardi, Giorgio</creator><creator>Olofsson, Birgitta</creator><creator>Filipski, Jan</creator><creator>Zerial, Marino</creator><creator>Salinas, Julio</creator><creator>Cuny, Gerard</creator><creator>Meunier-Rotival, Michele</creator><creator>Rodier, Francis</creator><general>The American Association for the Advancement of Science</general><general>American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19850524</creationdate><title>The Mosaic Genome of Warm-Blooded Vertebrates</title><author>Bernardi, Giorgio ; Olofsson, Birgitta ; Filipski, Jan ; Zerial, Marino ; Salinas, Julio ; Cuny, Gerard ; Meunier-Rotival, Michele ; Rodier, Francis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c706t-71799fefca62791089a8fb129639a9a9084d88426b2065cda5d9b75dbd9ece0a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Animals</topic><topic>Base Composition</topic><topic>Base Sequence</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Biological Evolution</topic><topic>Centrifugation, Density Gradient</topic><topic>Chickens</topic><topic>Chickens - genetics</topic><topic>Chromosome Banding</topic><topic>Chromosomes</topic><topic>Codon</topic><topic>Codons</topic><topic>Cytosine - analysis</topic><topic>DNA - analysis</topic><topic>DNA - genetics</topic><topic>DNA Replication</topic><topic>DNA, Viral - genetics</topic><topic>Evolution</topic><topic>Evolution (Biology)</topic><topic>Exons</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Amplification</topic><topic>Genes</topic><topic>Genes, Viral</topic><topic>Genes. Genome</topic><topic>Genetic aspects</topic><topic>Genomes</topic><topic>Globular star clusters</topic><topic>Guanine - analysis</topic><topic>Humans</topic><topic>Introns</topic><topic>Isochores</topic><topic>Mammals - genetics</topic><topic>Mice - genetics</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Mutation</topic><topic>Nucleic acids</topic><topic>Rabbits - genetics</topic><topic>Recombination, Genetic</topic><topic>Repetitive Sequences, Nucleic Acid</topic><topic>Vertebrata</topic><topic>Vertebrates</topic><topic>Xenopus - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bernardi, Giorgio</creatorcontrib><creatorcontrib>Olofsson, Birgitta</creatorcontrib><creatorcontrib>Filipski, Jan</creatorcontrib><creatorcontrib>Zerial, Marino</creatorcontrib><creatorcontrib>Salinas, Julio</creatorcontrib><creatorcontrib>Cuny, Gerard</creatorcontrib><creatorcontrib>Meunier-Rotival, Michele</creatorcontrib><creatorcontrib>Rodier, Francis</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: High School</collection><collection>Biography resource center</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Canada</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bernardi, Giorgio</au><au>Olofsson, Birgitta</au><au>Filipski, Jan</au><au>Zerial, Marino</au><au>Salinas, Julio</au><au>Cuny, Gerard</au><au>Meunier-Rotival, Michele</au><au>Rodier, Francis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Mosaic Genome of Warm-Blooded Vertebrates</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1985-05-24</date><risdate>1985</risdate><volume>228</volume><issue>4702</issue><spage>953</spage><epage>958</epage><pages>953-958</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Most of the nuclear genome of warm-blooded vertebrates is a mosaic of very long (>>200 kilobases) DNA segments, the isochores; these isochores are fairly homogeneous in base composition and belong to a small number of major classes distinguished by differences in guanine-cytosine (GC) content. The families of DNA molecules derived from such classes can be separated and used to study the genome distribution of any sequence which can be probed. This approach has revealed (i) that the distribution of genes, integrated viral sequences, and interspersed repeats is highly nonuniform in the genome, and (ii) that the base composition and ratio of CpG to GpC in both coding and noncoding sequences, as well as codon usage, mainly depend on the GC content of the isochores harboring the sequences. The compositional compartmentalization of the genome of warm-blooded vertebrates is discussed with respect to its evolutionary origin, its causes, and its effects on chromosome structure and function.</abstract><cop>Washington, DC</cop><pub>The American Association for the Advancement of Science</pub><pmid>4001930</pmid><doi>10.1126/science.4001930</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1985-05, Vol.228 (4702), p.953-958 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76145885 |
| source | American Association for the Advancement of Science; JSTOR Archival Journals and Primary Sources Collection |
| subjects | Animals Base Composition Base Sequence Biochemistry Biological and medical sciences Biological Evolution Centrifugation, Density Gradient Chickens Chickens - genetics Chromosome Banding Chromosomes Codon Codons Cytosine - analysis DNA - analysis DNA - genetics DNA Replication DNA, Viral - genetics Evolution Evolution (Biology) Exons Fundamental and applied biological sciences. Psychology Gene Amplification Genes Genes, Viral Genes. Genome Genetic aspects Genomes Globular star clusters Guanine - analysis Humans Introns Isochores Mammals - genetics Mice - genetics Molecular and cellular biology Molecular genetics Mutation Nucleic acids Rabbits - genetics Recombination, Genetic Repetitive Sequences, Nucleic Acid Vertebrata Vertebrates Xenopus - genetics |
| title | The Mosaic Genome of Warm-Blooded Vertebrates |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T11%3A31%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Mosaic%20Genome%20of%20Warm-Blooded%20Vertebrates&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Bernardi,%20Giorgio&rft.date=1985-05-24&rft.volume=228&rft.issue=4702&rft.spage=953&rft.epage=958&rft.pages=953-958&rft.issn=0036-8075&rft.eissn=1095-9203&rft.coden=SCIEAS&rft_id=info:doi/10.1126/science.4001930&rft_dat=%3Cgale_proqu%3EA3783782%3C/gale_proqu%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c706t-71799fefca62791089a8fb129639a9a9084d88426b2065cda5d9b75dbd9ece0a3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=14352475&rft_id=info:pmid/4001930&rft_galeid=A3783782&rft_jstor_id=1694234&rfr_iscdi=true |