Human stratum corneum polar lipids and desquamation

The ceramides and steryl-sulfate components from desquamated and cohesive human stratum corneum were examined using a combination of chemical and chromatographic means. Six structurally distinct series of ceramides were identified, and the relative amounts of these species, as measured by quantitati...

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Bibliographic Details
Published in:Archives of Dermatological Research 1985-01, Vol.277 (4), p.284-287
Main Authors: LONG, S. A, WERTZ, P. W, STRAUSS, J. S, DOWNING, D. T
Format: Article
Language:English
Subjects:
Biological and medical sciences
Ceramides - analysis
Cholesterol Esters - analysis
Chromatography, Thin Layer
Epidermis - analysis
Fundamental and applied biological sciences. Psychology
Humans
Lipids - analysis
Vertebrates: skin, associated glands, phaneres, light organs, various exocrine glands (salt gland, uropygial gland...), adipose tissue, connective tissue
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Summary:The ceramides and steryl-sulfate components from desquamated and cohesive human stratum corneum were examined using a combination of chemical and chromatographic means. Six structurally distinct series of ceramides were identified, and the relative amounts of these species, as measured by quantitative thin-layer chromatography, did not differ in cohesive and desquamated stratum corneum. In contrast, the level of cholesteryl sulfate was significantly reduced in the desquamated material. The results are in accord with the hypothesis that cholesteryl sulfate serves in cell-to-cell cohesion within the stratum corneum, and its hydrolysis may be necessary to permit shedding of cells from the surface.
ISSN:0340-3696
1432-069X
DOI:10.1007/BF00509081