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Human stratum corneum polar lipids and desquamation

The ceramides and steryl-sulfate components from desquamated and cohesive human stratum corneum were examined using a combination of chemical and chromatographic means. Six structurally distinct series of ceramides were identified, and the relative amounts of these species, as measured by quantitati...

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Published in:	Archives of Dermatological Research 1985-01, Vol.277 (4), p.284-287
Main Authors:	LONG, S. A, WERTZ, P. W, STRAUSS, J. S, DOWNING, D. T
Format:	Article
Language:	English
Subjects:	Biological and medical sciences Ceramides - analysis Cholesterol Esters - analysis Chromatography, Thin Layer Epidermis - analysis Fundamental and applied biological sciences. Psychology Humans Lipids - analysis Vertebrates: skin, associated glands, phaneres, light organs, various exocrine glands (salt gland, uropygial gland...), adipose tissue, connective tissue
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description	The ceramides and steryl-sulfate components from desquamated and cohesive human stratum corneum were examined using a combination of chemical and chromatographic means. Six structurally distinct series of ceramides were identified, and the relative amounts of these species, as measured by quantitative thin-layer chromatography, did not differ in cohesive and desquamated stratum corneum. In contrast, the level of cholesteryl sulfate was significantly reduced in the desquamated material. The results are in accord with the hypothesis that cholesteryl sulfate serves in cell-to-cell cohesion within the stratum corneum, and its hydrolysis may be necessary to permit shedding of cells from the surface.
doi_str_mv	10.1007/BF00509081
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subjects	Biological and medical sciences Ceramides - analysis Cholesterol Esters - analysis Chromatography, Thin Layer Epidermis - analysis Fundamental and applied biological sciences. Psychology Humans Lipids - analysis Vertebrates: skin, associated glands, phaneres, light organs, various exocrine glands (salt gland, uropygial gland...), adipose tissue, connective tissue
title	Human stratum corneum polar lipids and desquamation
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