Lidocaine Infusion in a Critical Region of Cerebellum Completely Prevents Learning of the Conditioned Eyeblink Response

New Zealand white rabbits were implanted with cannulas in the dorsal or ventral aspect of the anterior interpositus nucleus. Three days (and 6 days for some dorsal-infusion animals) of standard tone-airpuff training was given with continuous infusion (constant rate of 0.2 μL/min) of lidocaine or sal...

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Bibliographic Details
Published in:Behavioral neuroscience 1993-10, Vol.107 (5), p.882-886
Main Authors: Nordholm, Alan F, Thompson, Judith K, Dersarkissian, Carol, Thompson, Richard F
Format: Article
Language:English
Subjects:
Anatomical correlates of behavior
Animal
Animal behavior
Animals
Association Learning - drug effects
Association Learning - physiology
Behavioral psychophysiology
Biological and medical sciences
Blinking - drug effects
Blinking - physiology
Brain Mapping
Cerebellar Nuclei - drug effects
Cerebellar Nuclei - physiology
Cerebellum
Conditioning, Classical - drug effects
Conditioning, Classical - physiology
Dominance, Cerebral - drug effects
Dominance, Cerebral - physiology
Eyelid Conditioning
Eyes & eyesight
Fundamental and applied biological sciences. Psychology
Lidocaine
Lidocaine - pharmacology
Memory
Mental Recall - drug effects
Mental Recall - physiology
Neurology
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Rabbits
Transplants & implants
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Summary:New Zealand white rabbits were implanted with cannulas in the dorsal or ventral aspect of the anterior interpositus nucleus. Three days (and 6 days for some dorsal-infusion animals) of standard tone-airpuff training was given with continuous infusion (constant rate of 0.2 μL/min) of lidocaine or saline. All animals were then given 3 days of training with no infusion. All lidocine-infused animals exhibited no conditioned responses in the 3 or 6 days of infusion training. Dorsal-infusion animals learned in the subsequent 3 days of no infusion training as if naive, that is they exhibited no savings. Animals with ventral cannula locations learned during infusion training, as shown in postinfusion training. These results strongly support the hypothesis that the essential memory trace for eyeblink conditioning is formed and stored in the cerebellum.
ISSN:0735-7044
1939-0084
DOI:10.1037/0735-7044.107.5.882