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Corticosteroid Induction of Threat-Induced Behavioral Inhibition in Preweanling Rats
Termination of ongoing behavior and assumption of defensive postures when threatened are adaptive characteristics of vertebrates. Altricial rat pups develop these characteristics by 14 days of age. At this time, pups inhibit their ultrasonic vocalizations and freeze when threatened. This emergence o...
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| Published in: | Behavioral neuroscience 1993-10, Vol.107 (5), p.860-866 |
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| Language: | English |
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| container_end_page | 866 |
| container_issue | 5 |
| container_start_page | 860 |
| container_title | Behavioral neuroscience |
| container_volume | 107 |
| creator | Takahashi, Lorey K Rubin, William W |
| description | Termination of ongoing behavior and assumption of defensive postures when threatened are adaptive characteristics of vertebrates. Altricial rat pups develop these characteristics by 14 days of age. At this time, pups inhibit their ultrasonic vocalizations and freeze when threatened. This emergence of behavioral inhibition is impaired when rats are adrenalectomized (ADX) at 10 days of age. That is, 14-day-old ADX pups exhibit deficits in freezing and continue to emit ultrasounds when confronted by an adult male rat. Studies also showed that removal of adrenal hormones does not potentiate vocalizations or render pups incapable of reducing their ultrasounds. More important, 3.0 mg/kg of corticosterone (CORT), but not lower doses, administered daily to ADX pups restored freezing, with lesser effects on ultrasound inhibition. Disrupting the developmental action of endogenous CORT appears to impair the ontogenetic expression of behavioral inhibition. |
| doi_str_mv | 10.1037/0735-7044.107.5.860 |
| format | article |
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Altricial rat pups develop these characteristics by 14 days of age. At this time, pups inhibit their ultrasonic vocalizations and freeze when threatened. This emergence of behavioral inhibition is impaired when rats are adrenalectomized (ADX) at 10 days of age. That is, 14-day-old ADX pups exhibit deficits in freezing and continue to emit ultrasounds when confronted by an adult male rat. Studies also showed that removal of adrenal hormones does not potentiate vocalizations or render pups incapable of reducing their ultrasounds. More important, 3.0 mg/kg of corticosterone (CORT), but not lower doses, administered daily to ADX pups restored freezing, with lesser effects on ultrasound inhibition. Disrupting the developmental action of endogenous CORT appears to impair the ontogenetic expression of behavioral inhibition.</description><identifier>ISSN: 0735-7044</identifier><identifier>EISSN: 1939-0084</identifier><identifier>DOI: 10.1037/0735-7044.107.5.860</identifier><identifier>PMID: 8280395</identifier><identifier>CODEN: BENEDJ</identifier><language>eng</language><publisher>Washington, DC: American Psychological Association</publisher><subject>Adrenalectomy ; Animal ; Animal behavior ; Animal Defensive Behavior ; Animal Vocalizations ; Animals ; Animals, Newborn ; Arousal - physiology ; Behavioral Inhibition ; Behavioral psychophysiology ; Biological and medical sciences ; Corticosterone ; Corticosterone - blood ; Fear - physiology ; Female ; Fundamental and applied biological sciences. Psychology ; Hormones and behavior ; Infants (Animal) ; Male ; Motor Activity - physiology ; Neurology ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Rats ; Rats, Sprague-Dawley ; Receptors, Steroid - physiology ; Rodents ; Steroids ; Threat ; Ultrasound</subject><ispartof>Behavioral neuroscience, 1993-10, Vol.107 (5), p.860-866</ispartof><rights>1993 American Psychological Association</rights><rights>1994 INIST-CNRS</rights><rights>Copyright American Psychological Association Oct 1993</rights><rights>1993, American Psychological Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a547t-dd168158d9022fd8d43de74010ac39427ec5b6334b25f3710aef4092cc6b65d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3794273$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8280395$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Squire, Larry R</contributor><creatorcontrib>Takahashi, Lorey K</creatorcontrib><creatorcontrib>Rubin, William W</creatorcontrib><title>Corticosteroid Induction of Threat-Induced Behavioral Inhibition in Preweanling Rats</title><title>Behavioral neuroscience</title><addtitle>Behav Neurosci</addtitle><description>Termination of ongoing behavior and assumption of defensive postures when threatened are adaptive characteristics of vertebrates. Altricial rat pups develop these characteristics by 14 days of age. At this time, pups inhibit their ultrasonic vocalizations and freeze when threatened. This emergence of behavioral inhibition is impaired when rats are adrenalectomized (ADX) at 10 days of age. That is, 14-day-old ADX pups exhibit deficits in freezing and continue to emit ultrasounds when confronted by an adult male rat. Studies also showed that removal of adrenal hormones does not potentiate vocalizations or render pups incapable of reducing their ultrasounds. More important, 3.0 mg/kg of corticosterone (CORT), but not lower doses, administered daily to ADX pups restored freezing, with lesser effects on ultrasound inhibition. Disrupting the developmental action of endogenous CORT appears to impair the ontogenetic expression of behavioral inhibition.</description><subject>Adrenalectomy</subject><subject>Animal</subject><subject>Animal behavior</subject><subject>Animal Defensive Behavior</subject><subject>Animal Vocalizations</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Arousal - physiology</subject><subject>Behavioral Inhibition</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Corticosterone</subject><subject>Corticosterone - blood</subject><subject>Fear - physiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hormones and behavior</subject><subject>Infants (Animal)</subject><subject>Male</subject><subject>Motor Activity - physiology</subject><subject>Neurology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Steroid - physiology</subject><subject>Rodents</subject><subject>Steroids</subject><subject>Threat</subject><subject>Ultrasound</subject><issn>0735-7044</issn><issn>1939-0084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><recordid>eNqFkVtrFDEUgINY6lr9BSIMYn1y1twvj7p4KRQqsu8hk2TclNlkTWYq_ffNdJcFi7TkIZxzvnNy-QB4g-ASQSI-QUFYKyClNRRLtpQcPgMLpIhqIZT0OVgciRfgZSnXEEIKKTsFpxJLSBRbgPUq5THYVEafU3DNRXSTHUOKTeqb9SZ7M7b3Oe-aL35jbkLKZqjYJnThngux-Zn9X2_iEOLv5pcZyytw0puh-NeH_Qysv31dr360l1ffL1afL1vDqBhb5xCXiEmnIMa9k44S5wWFCBpLFMXCW9ZxQmiHWU9ETfueQoWt5R1njpyBD_uxu5z-TL6MehuK9cNgok9T0YIjRhRmT4L1GhwhiSv47gF4naYc6xs0R5TUJeljEIZEKkW5rBDZQzanUrLv9S6Hrcm3GkE929OzGz27qaHQTFd7tevtYfTUbb079hx01fr7Q90Ua4Y-m2hDOWJEzL9GKvZxj5md0btya83sePDFTjn7OOou-n9OPf8__oC7AwWSvFY</recordid><startdate>19931001</startdate><enddate>19931001</enddate><creator>Takahashi, Lorey K</creator><creator>Rubin, William W</creator><general>American Psychological Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7RZ</scope><scope>PSYQQ</scope><scope>7X8</scope></search><sort><creationdate>19931001</creationdate><title>Corticosteroid Induction of Threat-Induced Behavioral Inhibition in Preweanling Rats</title><author>Takahashi, Lorey K ; Rubin, William W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a547t-dd168158d9022fd8d43de74010ac39427ec5b6334b25f3710aef4092cc6b65d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adrenalectomy</topic><topic>Animal</topic><topic>Animal behavior</topic><topic>Animal Defensive Behavior</topic><topic>Animal Vocalizations</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Arousal - physiology</topic><topic>Behavioral Inhibition</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Corticosterone</topic><topic>Corticosterone - blood</topic><topic>Fear - physiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hormones and behavior</topic><topic>Infants (Animal)</topic><topic>Male</topic><topic>Motor Activity - physiology</topic><topic>Neurology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, Steroid - physiology</topic><topic>Rodents</topic><topic>Steroids</topic><topic>Threat</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takahashi, Lorey K</creatorcontrib><creatorcontrib>Rubin, William W</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>APA PsycArticles®</collection><collection>ProQuest One Psychology</collection><collection>MEDLINE - Academic</collection><jtitle>Behavioral neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takahashi, Lorey K</au><au>Rubin, William W</au><au>Squire, Larry R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Corticosteroid Induction of Threat-Induced Behavioral Inhibition in Preweanling Rats</atitle><jtitle>Behavioral neuroscience</jtitle><addtitle>Behav Neurosci</addtitle><date>1993-10-01</date><risdate>1993</risdate><volume>107</volume><issue>5</issue><spage>860</spage><epage>866</epage><pages>860-866</pages><issn>0735-7044</issn><eissn>1939-0084</eissn><coden>BENEDJ</coden><abstract>Termination of ongoing behavior and assumption of defensive postures when threatened are adaptive characteristics of vertebrates. Altricial rat pups develop these characteristics by 14 days of age. At this time, pups inhibit their ultrasonic vocalizations and freeze when threatened. This emergence of behavioral inhibition is impaired when rats are adrenalectomized (ADX) at 10 days of age. That is, 14-day-old ADX pups exhibit deficits in freezing and continue to emit ultrasounds when confronted by an adult male rat. Studies also showed that removal of adrenal hormones does not potentiate vocalizations or render pups incapable of reducing their ultrasounds. More important, 3.0 mg/kg of corticosterone (CORT), but not lower doses, administered daily to ADX pups restored freezing, with lesser effects on ultrasound inhibition. Disrupting the developmental action of endogenous CORT appears to impair the ontogenetic expression of behavioral inhibition.</abstract><cop>Washington, DC</cop><pub>American Psychological Association</pub><pmid>8280395</pmid><doi>10.1037/0735-7044.107.5.860</doi><tpages>7</tpages></addata></record> |
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| ispartof | Behavioral neuroscience, 1993-10, Vol.107 (5), p.860-866 |
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| language | eng |
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| subjects | Adrenalectomy Animal Animal behavior Animal Defensive Behavior Animal Vocalizations Animals Animals, Newborn Arousal - physiology Behavioral Inhibition Behavioral psychophysiology Biological and medical sciences Corticosterone Corticosterone - blood Fear - physiology Female Fundamental and applied biological sciences. Psychology Hormones and behavior Infants (Animal) Male Motor Activity - physiology Neurology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Sprague-Dawley Receptors, Steroid - physiology Rodents Steroids Threat Ultrasound |
| title | Corticosteroid Induction of Threat-Induced Behavioral Inhibition in Preweanling Rats |
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