Influence of acute-phase proteins on the activity of natural Killer cells

The effects of alpha 1-antitrypsin (alpha 1-AT), alpha 1-acid glycoprotein (alpha 1-AGP), and haptoglobin (Hp), the main constituents of alpha-globulin and which belong to acute-phase proteins, on NK activity were examined using K562 cells as the NK target cells. Among the three proteins, alpha 1-AT...

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Bibliographic Details
Published in:Inflammation 1985-06, Vol.9 (2), p.211-219
Main Authors: OKUMURA, Y, KUDO, J, IKUTA, T, KUROKAWA, S, ISHIBASHI, H, OKUBO, H
Format: Article
Language:English
Subjects:
Albumins - pharmacology
alpha 1-Antitrypsin - pharmacology
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Haptoglobins - pharmacology
Humans
Immunity, Innate - drug effects
Inflammation
Killer Cells, Natural - immunology
Molecular and cellular biology
Orosomucoid - pharmacology
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Summary:The effects of alpha 1-antitrypsin (alpha 1-AT), alpha 1-acid glycoprotein (alpha 1-AGP), and haptoglobin (Hp), the main constituents of alpha-globulin and which belong to acute-phase proteins, on NK activity were examined using K562 cells as the NK target cells. Among the three proteins, alpha 1-AT and alpha 1-AGP had inhibitory effects on NK activity for "fast target" K562 cells. The alpha 1-AT preparations having the same protein concentration and a different trypsin inhibitory capacity (TIC) had an equal effect. Although alpha 1-AT and alpha 1-AGP equally reduced the NK activity, the mechanism involved in the reduction differed, in that the effect of alpha 1-AT directed toward NK cells reduced their binding capacity with the target cells. alpha 1-AGP probably interacts with a cytotoxic factor secreted from NK cells following effector-target interaction. These studies suggest that each of the acute-phase proteins, which increase following inflammation, inhibits NK cell function by two distinct mechanisms.
ISSN:0360-3997
1573-2576
DOI:10.1007/BF00917593