A Comparison of Pneumonia Caused by Gentamicin, Methicillin-Resistant and Gentamicin, Methicillin-Sensitive Staphylococcus aureus: Epidemiologic and Clinical Studies

We investigated an outbreak of nosocomial pneumonia due to gentamicin, methicillin-resistant Staphylococcus aureus (GMRSA). We compared the predisposing factors for pneunomia due to GMRSA to those for pneumonia due to gentamicin, methicillin-sensitive Staphylococcus aureus (GMSSA). Seventeen of 29 p...

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Bibliographic Details
Published in:Infection control : IC 1985-07, Vol.6 (7), p.267-272
Main Authors: Lentino, Joseph R., Hennein, Hani, Krause, Sally, Pappas, Sharon, Fuller, Gail, Schaaff, Doris, DiCostanzo, Mary Beth
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - therapeutic use
Antibiotics
Cross Infection - drug therapy
Cross Infection - epidemiology
Cross Infection - microbiology
Disease Outbreaks - epidemiology
Epidemiology
Gentamicins - pharmacology
Hospital administration
Hospitals, Veterans
Humans
Illinois
Infections
Lung diseases
Methicillin - pharmacology
Nursing
Penicillin Resistance
Pneumonia
Pneumonia, Staphylococcal - drug therapy
Pneumonia, Staphylococcal - epidemiology
Pneumonia, Staphylococcal - microbiology
Predisposing factors
Risk
Staphylococcal pneumonia
Staphylococcus
Staphylococcus aureus
Staphylococcus aureus - drug effects
Staphylococcus aureus - pathogenicity
Time Factors
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Summary:We investigated an outbreak of nosocomial pneumonia due to gentamicin, methicillin-resistant Staphylococcus aureus (GMRSA). We compared the predisposing factors for pneunomia due to GMRSA to those for pneumonia due to gentamicin, methicillin-sensitive Staphylococcus aureus (GMSSA). Seventeen of 29 patients with staphylococcal pneumonia were infected with GMRSA. Risk factors and associated diseases which selected for infection with GMRSA as opposed to GMSSA included prior antibiotic therapy for a prolonged period of time (p = 0.0001), number of risk factors per patient (p = 0.0001), days hospitalized prior to diagnosis of pneumonia (p = 0.002) and number of associated diseases per patient (p = 0.002). Despite the epidemiologic differences between GMSSA and GMRSA pneumonia, there were no differences in the clinical presentation, course of illness, complications, response to appropriate therapy or outcome between the two groups. Survival was adversely affected by age only among the GMSSA patients (p = 0.02) and by the number of associated diseases (p = 0.005).
ISSN:0195-9417
2327-9451
DOI:10.1017/S0195941700061737