Detection of Herpes Simplex Virus in Women with Acute Pelvic Inflammatory Disease

Four women are described with acute salpingitis confirmed by laparoscopy who had herpes simplex virus(HSY) isolated from the cervix or the upper genital tract (endometrium, fallopian tube, or cul-de-sac) or both. None of the patients had overt genital herpes, but one had typical HSV cervitis on a ce...

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Bibliographic Details
Published in:The Journal of infectious diseases 1985-07, Vol.152 (1), p.78-82
Main Authors: Lehtinen, Matti, Rantala, Immo, Teisala, Klaus, Heinonen, Pentti K., Lehtinen, Tuula, Aine, Risto, Miettinen, Ari, Gronroos, Paul, Punnonen, Reijo, Lelnlkkl, Pauli, Paavonen, Jorma
Format: Article
Language:English
Subjects:
Adolescent
Adult
Antibodies
Antibodies, Viral - analysis
Antigens
Biological and medical sciences
Biopsies
Cell Line
Cervix Uteri - microbiology
Cytopathogenic Effect, Viral
Endometrium - microbiology
Fallopian Tubes - microbiology
Female
Herpes Genitalis - complications
herpes simplex virus
Human herpesvirus 1
Human herpesvirus 2
Human viral diseases
Humans
Infections
Infectious diseases
Male
Medical sciences
Original Articles
Pelvic inflammatory disease
Salpingitis - complications
Salpingitis - immunology
Salpingitis - microbiology
Simplexvirus
Simplexvirus - classification
Simplexvirus - immunology
Simplexvirus - isolation & purification
Simplexvirus - physiology
Vero cells
Viral diseases
Viral diseases of the genital and urinary system
Viral Plaque Assay
Viruses
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Description
Summary:Four women are described with acute salpingitis confirmed by laparoscopy who had herpes simplex virus(HSY) isolated from the cervix or the upper genital tract (endometrium, fallopian tube, or cul-de-sac) or both. None of the patients had overt genital herpes, but one had typical HSV cervitis on a cervicovaginal smear stained with Papanicolaou's stain, one had a significant change in level of antibodies to HSV, and one had an endometrial biopsy specimen positive for HSV antigen. There are at least three potential explanations for these findings: chronic viral shedding, viral reactivation caused by acute pelvic inflammatory disease(PID), or that the PID was actually caused by HSV. Further prospective studies are needed to document the role of HSY in causing PID.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/152.1.78