Bioactive Marine Metabolites, IV. Isolation and the Amino Acid Composition of Discodermin A, an Antimicrobial Peptide, from the Marine Sponge Discodermia kiiensis

An antimicrobial peptide, discodermin A, has been isolated from the marine sponge Discodermia kiiensis. The peptide showed antimicrobial activity as well as an inhibition of starfish embryo development. It appeared to be a tetradecapeptide consisting of D-Cys(O3H), L-Asp, L-MeGlu, L-Thr (2 moles), S...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1985-03, Vol.48 (2), p.236-241
Main Authors: Matsunaga, Shigeki, Fusetani, Nobuhiro, Konosu, Shoji
Format: Article
Language:English
Subjects:
Amino Acids - analysis
Amphibian Proteins
Animals
Antimicrobial Cationic Peptides
Bacteria - drug effects
Biological and medical sciences
Electrophoresis, Paper
General pharmacology
Magnetic Resonance Spectroscopy
Medical sciences
Microbial Sensitivity Tests
Peptides - analysis
Peptides - isolation & purification
Peptides - pharmacology
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Porifera - metabolism
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Summary:An antimicrobial peptide, discodermin A, has been isolated from the marine sponge Discodermia kiiensis. The peptide showed antimicrobial activity as well as an inhibition of starfish embryo development. It appeared to be a tetradecapeptide consisting of D-Cys(O3H), L-Asp, L-MeGlu, L-Thr (2 moles), Sar, D-Pro, D-Ala, D- and L-t-Leu, D-Leu, L-Phe, D-Trp, and L-Arg.
ISSN:0163-3864
1520-6025
DOI:10.1021/np50038a006