Loading…
Interaction of Epothilone B (Patupilone) with Microtubules as Detected by Two-Dimensional Solid-State NMR Spectroscopy
Solid evidence: Induction of the polymerization of αβ‐tubulin dimers into microtubules by epothilones, such as patupilone, by an as yet unknown mechanism leads to the apoptosis of cancer cells. Solid‐state NMR spectroscopy of patupilone bound to microtubules has now enabled the identification of ato...
Saved in:
| Published in: | Angewandte Chemie (International ed.) 2010-10, Vol.49 (41), p.7504-7507 |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c4066-43b08d9c51fe6c8b695f99b6b3acaa4e3743adbc7ef36aa4143852fb743205673 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c4066-43b08d9c51fe6c8b695f99b6b3acaa4e3743adbc7ef36aa4143852fb743205673 |
| container_end_page | 7507 |
| container_issue | 41 |
| container_start_page | 7504 |
| container_title | Angewandte Chemie (International ed.) |
| container_volume | 49 |
| creator | Kumar, Ashutosh Heise, Henrike Blommers, Marcel J.J Krastel, Philipp Schmitt, Esther Petersen, Frank Jeganathan, Siva Mandelkow, Eva-Maria Carlomagno, Teresa Griesinger, Christian Baldus, Marc |
| description | Solid evidence: Induction of the polymerization of αβ‐tubulin dimers into microtubules by epothilones, such as patupilone, by an as yet unknown mechanism leads to the apoptosis of cancer cells. Solid‐state NMR spectroscopy of patupilone bound to microtubules has now enabled the identification of atomic positions of the drug that undergo clear chemical‐shift changes upon binding (see correlation spectra of free (black) and complexed patupilone (red)). |
| doi_str_mv | 10.1002/anie.201001946 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_762020126</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>762020126</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4066-43b08d9c51fe6c8b695f99b6b3acaa4e3743adbc7ef36aa4143852fb743205673</originalsourceid><addsrcrecordid>eNqFkMFv0zAUhyMEYmNw5Qi-DQ4pjh3b8XHtulFpK4hu4mg5zgszpHGwHbr-93hkVNw4-fnpe5_0-2XZ6wLPCozJB91bmBGc5kKW_El2XDBS5FQI-jTNJaW5qFhxlL0I4Xviqwrz59kRwRWWjPHj7Neqj-C1idb1yLVoObh4ZzvXA5qjd591HIc_v_doZ-MdurbGuzjWYwcB6YDOIYKJ0KB6j252Lj-3W-hDcukObVxnm3wTdQS0vv6CNkNCvQvGDfuX2bNWdwFePb4n2e3F8mbxMb_6dLlanF3lpsSc5yWtcdVIw4oWuKlqLlkrZc1rqo3WJVBRUt3URkBLeVqkwBUjbZ3WBDMu6El2OnkH736OEKLa2mCg63QPbgxKcIJTe4QncjaRKWAIHlo1eLvVfq8KrB6qVg9Vq0PV6eDNo3qst9Ac8L_dJkBOwM52sP-PTp2tV8t_5fl0a0OE-8Ot9j9USiWY-rq-VKVcrPmczNUi8W8nvtVO6W_eBnW7STqKi0oyUWL6G6aqo6M</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>762020126</pqid></control><display><type>article</type><title>Interaction of Epothilone B (Patupilone) with Microtubules as Detected by Two-Dimensional Solid-State NMR Spectroscopy</title><source>Wiley</source><creator>Kumar, Ashutosh ; Heise, Henrike ; Blommers, Marcel J.J ; Krastel, Philipp ; Schmitt, Esther ; Petersen, Frank ; Jeganathan, Siva ; Mandelkow, Eva-Maria ; Carlomagno, Teresa ; Griesinger, Christian ; Baldus, Marc</creator><creatorcontrib>Kumar, Ashutosh ; Heise, Henrike ; Blommers, Marcel J.J ; Krastel, Philipp ; Schmitt, Esther ; Petersen, Frank ; Jeganathan, Siva ; Mandelkow, Eva-Maria ; Carlomagno, Teresa ; Griesinger, Christian ; Baldus, Marc</creatorcontrib><description>Solid evidence: Induction of the polymerization of αβ‐tubulin dimers into microtubules by epothilones, such as patupilone, by an as yet unknown mechanism leads to the apoptosis of cancer cells. Solid‐state NMR spectroscopy of patupilone bound to microtubules has now enabled the identification of atomic positions of the drug that undergo clear chemical‐shift changes upon binding (see correlation spectra of free (black) and complexed patupilone (red)).</description><identifier>ISSN: 1433-7851</identifier><identifier>EISSN: 1521-3773</identifier><identifier>DOI: 10.1002/anie.201001946</identifier><identifier>PMID: 20809556</identifier><language>eng</language><publisher>Weinheim: Wiley-VCH Verlag</publisher><subject>Antineoplastic Agents - isolation & purification ; Antineoplastic Agents - pharmacology ; antitumor agents ; drug binding ; Epothilones - isolation & purification ; Epothilones - pharmacology ; Humans ; microtubules ; Microtubules - metabolism ; Microtubules - ultrastructure ; Models, Molecular ; Myxococcales - chemistry ; Neoplasms - drug therapy ; NMR spectroscopy ; Nuclear Magnetic Resonance, Biomolecular - methods ; structure elucidation ; Tubulin - metabolism ; Tubulin Modulators - isolation & purification ; Tubulin Modulators - pharmacology</subject><ispartof>Angewandte Chemie (International ed.), 2010-10, Vol.49 (41), p.7504-7507</ispartof><rights>Copyright © 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4066-43b08d9c51fe6c8b695f99b6b3acaa4e3743adbc7ef36aa4143852fb743205673</citedby><cites>FETCH-LOGICAL-c4066-43b08d9c51fe6c8b695f99b6b3acaa4e3743adbc7ef36aa4143852fb743205673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20809556$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kumar, Ashutosh</creatorcontrib><creatorcontrib>Heise, Henrike</creatorcontrib><creatorcontrib>Blommers, Marcel J.J</creatorcontrib><creatorcontrib>Krastel, Philipp</creatorcontrib><creatorcontrib>Schmitt, Esther</creatorcontrib><creatorcontrib>Petersen, Frank</creatorcontrib><creatorcontrib>Jeganathan, Siva</creatorcontrib><creatorcontrib>Mandelkow, Eva-Maria</creatorcontrib><creatorcontrib>Carlomagno, Teresa</creatorcontrib><creatorcontrib>Griesinger, Christian</creatorcontrib><creatorcontrib>Baldus, Marc</creatorcontrib><title>Interaction of Epothilone B (Patupilone) with Microtubules as Detected by Two-Dimensional Solid-State NMR Spectroscopy</title><title>Angewandte Chemie (International ed.)</title><addtitle>Angew. Chem. Int. Ed</addtitle><description>Solid evidence: Induction of the polymerization of αβ‐tubulin dimers into microtubules by epothilones, such as patupilone, by an as yet unknown mechanism leads to the apoptosis of cancer cells. Solid‐state NMR spectroscopy of patupilone bound to microtubules has now enabled the identification of atomic positions of the drug that undergo clear chemical‐shift changes upon binding (see correlation spectra of free (black) and complexed patupilone (red)).</description><subject>Antineoplastic Agents - isolation & purification</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>antitumor agents</subject><subject>drug binding</subject><subject>Epothilones - isolation & purification</subject><subject>Epothilones - pharmacology</subject><subject>Humans</subject><subject>microtubules</subject><subject>Microtubules - metabolism</subject><subject>Microtubules - ultrastructure</subject><subject>Models, Molecular</subject><subject>Myxococcales - chemistry</subject><subject>Neoplasms - drug therapy</subject><subject>NMR spectroscopy</subject><subject>Nuclear Magnetic Resonance, Biomolecular - methods</subject><subject>structure elucidation</subject><subject>Tubulin - metabolism</subject><subject>Tubulin Modulators - isolation & purification</subject><subject>Tubulin Modulators - pharmacology</subject><issn>1433-7851</issn><issn>1521-3773</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNqFkMFv0zAUhyMEYmNw5Qi-DQ4pjh3b8XHtulFpK4hu4mg5zgszpHGwHbr-93hkVNw4-fnpe5_0-2XZ6wLPCozJB91bmBGc5kKW_El2XDBS5FQI-jTNJaW5qFhxlL0I4Xviqwrz59kRwRWWjPHj7Neqj-C1idb1yLVoObh4ZzvXA5qjd591HIc_v_doZ-MdurbGuzjWYwcB6YDOIYKJ0KB6j252Lj-3W-hDcukObVxnm3wTdQS0vv6CNkNCvQvGDfuX2bNWdwFePb4n2e3F8mbxMb_6dLlanF3lpsSc5yWtcdVIw4oWuKlqLlkrZc1rqo3WJVBRUt3URkBLeVqkwBUjbZ3WBDMu6El2OnkH736OEKLa2mCg63QPbgxKcIJTe4QncjaRKWAIHlo1eLvVfq8KrB6qVg9Vq0PV6eDNo3qst9Ac8L_dJkBOwM52sP-PTp2tV8t_5fl0a0OE-8Ot9j9USiWY-rq-VKVcrPmczNUi8W8nvtVO6W_eBnW7STqKi0oyUWL6G6aqo6M</recordid><startdate>20101004</startdate><enddate>20101004</enddate><creator>Kumar, Ashutosh</creator><creator>Heise, Henrike</creator><creator>Blommers, Marcel J.J</creator><creator>Krastel, Philipp</creator><creator>Schmitt, Esther</creator><creator>Petersen, Frank</creator><creator>Jeganathan, Siva</creator><creator>Mandelkow, Eva-Maria</creator><creator>Carlomagno, Teresa</creator><creator>Griesinger, Christian</creator><creator>Baldus, Marc</creator><general>Wiley-VCH Verlag</general><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20101004</creationdate><title>Interaction of Epothilone B (Patupilone) with Microtubules as Detected by Two-Dimensional Solid-State NMR Spectroscopy</title><author>Kumar, Ashutosh ; Heise, Henrike ; Blommers, Marcel J.J ; Krastel, Philipp ; Schmitt, Esther ; Petersen, Frank ; Jeganathan, Siva ; Mandelkow, Eva-Maria ; Carlomagno, Teresa ; Griesinger, Christian ; Baldus, Marc</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4066-43b08d9c51fe6c8b695f99b6b3acaa4e3743adbc7ef36aa4143852fb743205673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Antineoplastic Agents - isolation & purification</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>antitumor agents</topic><topic>drug binding</topic><topic>Epothilones - isolation & purification</topic><topic>Epothilones - pharmacology</topic><topic>Humans</topic><topic>microtubules</topic><topic>Microtubules - metabolism</topic><topic>Microtubules - ultrastructure</topic><topic>Models, Molecular</topic><topic>Myxococcales - chemistry</topic><topic>Neoplasms - drug therapy</topic><topic>NMR spectroscopy</topic><topic>Nuclear Magnetic Resonance, Biomolecular - methods</topic><topic>structure elucidation</topic><topic>Tubulin - metabolism</topic><topic>Tubulin Modulators - isolation & purification</topic><topic>Tubulin Modulators - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kumar, Ashutosh</creatorcontrib><creatorcontrib>Heise, Henrike</creatorcontrib><creatorcontrib>Blommers, Marcel J.J</creatorcontrib><creatorcontrib>Krastel, Philipp</creatorcontrib><creatorcontrib>Schmitt, Esther</creatorcontrib><creatorcontrib>Petersen, Frank</creatorcontrib><creatorcontrib>Jeganathan, Siva</creatorcontrib><creatorcontrib>Mandelkow, Eva-Maria</creatorcontrib><creatorcontrib>Carlomagno, Teresa</creatorcontrib><creatorcontrib>Griesinger, Christian</creatorcontrib><creatorcontrib>Baldus, Marc</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Angewandte Chemie (International ed.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kumar, Ashutosh</au><au>Heise, Henrike</au><au>Blommers, Marcel J.J</au><au>Krastel, Philipp</au><au>Schmitt, Esther</au><au>Petersen, Frank</au><au>Jeganathan, Siva</au><au>Mandelkow, Eva-Maria</au><au>Carlomagno, Teresa</au><au>Griesinger, Christian</au><au>Baldus, Marc</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interaction of Epothilone B (Patupilone) with Microtubules as Detected by Two-Dimensional Solid-State NMR Spectroscopy</atitle><jtitle>Angewandte Chemie (International ed.)</jtitle><addtitle>Angew. Chem. Int. Ed</addtitle><date>2010-10-04</date><risdate>2010</risdate><volume>49</volume><issue>41</issue><spage>7504</spage><epage>7507</epage><pages>7504-7507</pages><issn>1433-7851</issn><eissn>1521-3773</eissn><abstract>Solid evidence: Induction of the polymerization of αβ‐tubulin dimers into microtubules by epothilones, such as patupilone, by an as yet unknown mechanism leads to the apoptosis of cancer cells. Solid‐state NMR spectroscopy of patupilone bound to microtubules has now enabled the identification of atomic positions of the drug that undergo clear chemical‐shift changes upon binding (see correlation spectra of free (black) and complexed patupilone (red)).</abstract><cop>Weinheim</cop><pub>Wiley-VCH Verlag</pub><pmid>20809556</pmid><doi>10.1002/anie.201001946</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1433-7851 |
| ispartof | Angewandte Chemie (International ed.), 2010-10, Vol.49 (41), p.7504-7507 |
| issn | 1433-7851 1521-3773 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_762020126 |
| source | Wiley |
| subjects | Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology antitumor agents drug binding Epothilones - isolation & purification Epothilones - pharmacology Humans microtubules Microtubules - metabolism Microtubules - ultrastructure Models, Molecular Myxococcales - chemistry Neoplasms - drug therapy NMR spectroscopy Nuclear Magnetic Resonance, Biomolecular - methods structure elucidation Tubulin - metabolism Tubulin Modulators - isolation & purification Tubulin Modulators - pharmacology |
| title | Interaction of Epothilone B (Patupilone) with Microtubules as Detected by Two-Dimensional Solid-State NMR Spectroscopy |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T15%3A30%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Interaction%20of%20Epothilone%20B%20(Patupilone)%20with%20Microtubules%20as%20Detected%20by%20Two-Dimensional%20Solid-State%20NMR%20Spectroscopy&rft.jtitle=Angewandte%20Chemie%20(International%20ed.)&rft.au=Kumar,%20Ashutosh&rft.date=2010-10-04&rft.volume=49&rft.issue=41&rft.spage=7504&rft.epage=7507&rft.pages=7504-7507&rft.issn=1433-7851&rft.eissn=1521-3773&rft_id=info:doi/10.1002/anie.201001946&rft_dat=%3Cproquest_cross%3E762020126%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c4066-43b08d9c51fe6c8b695f99b6b3acaa4e3743adbc7ef36aa4143852fb743205673%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=762020126&rft_id=info:pmid/20809556&rfr_iscdi=true |