Developmental expression of sideroflexin family genes in Xenopus embryos

Emerging evidence indicates that mitochondrial carriers are not only crucial for metabolism, but also important for embryonic development. Sideroflexin is a novel family of mitochondrial tricarboxylate carrier proteins, of which the in vivo function is largely unknown. Here, we report on the express...

Full description

Saved in:
Bibliographic Details
Published in:Developmental dynamics 2010-10, Vol.239 (10), p.2742-2747
Main Authors: Li, Xiaojing, Han, Dandan, Kin Ting Kam, Richard, Guo, Xiaogang, Chen, Miao, Yang, Yong, Zhao, Hui, Chen, Yonglong
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Brain - embryology
Brain - metabolism
Cation Transport Proteins - chemistry
Cation Transport Proteins - classification
Cation Transport Proteins - genetics
Cation Transport Proteins - metabolism
Embryo, Nonmammalian - metabolism
Gene Expression Regulation, Developmental - genetics
Gene Expression Regulation, Developmental - physiology
Liver - embryology
Liver - metabolism
mitochondrial carrier
Molecular Sequence Data
pancreas
Pancreas - embryology
Pancreas - metabolism
Phylogeny
Sequence Homology, Amino Acid
sideroflexin
Xenopus
Xenopus laevis
Xenopus Proteins - chemistry
Xenopus Proteins - classification
Xenopus Proteins - genetics
Xenopus Proteins - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Emerging evidence indicates that mitochondrial carriers are not only crucial for metabolism, but also important for embryonic development. Sideroflexin is a novel family of mitochondrial tricarboxylate carrier proteins, of which the in vivo function is largely unknown. Here, we report on the expression patterns of five sideroflexin genes in Xenopus embryos. Whole‐mount in situ hybridization analysis reveals that while sideroflexin2 is expressed in the pancreas, sideroflexin1 and 3 display a complex expression in the central nervous system, somites, pronephros, liver, and pancreas. In contrast, only a weak expression of sideroflexin4 and 5 was detected in embryonic brain. Taken together, the five sideroflexin genes show both overlapping and nonoverlapping expression during Xenopus embryogenesis. As the primary structures of the five sideroflexin proteins are also quite similar, their functional redundancy should be taken into consideration for gene targeting studies. Developmental Dynamics 239:2742–2747, 2010. © 2010 Wiley‐Liss, Inc.
ISSN:1058-8388
1097-0177
DOI:10.1002/dvdy.22401