Bone turnover in male puberty: a longitudinal study

In a longitudinal study of male puberty, 18 boys were examined every 3 months for at least 2 years. Serum bone Gla protein (BGP), a biochemical marker of bone formation, was determined and related to changes in serum testosterone (T), serum alkaline phosphatase (AP), serum calcitonin, and bone miner...

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Published in:Calcified tissue international 1985-05, Vol.37 (3), p.213-217
Main Authors: RIIS, B. J, KRABBE, S, CHRISTIANSEN, C, CATHERWOOD, B. D, DEFTOS, L. J
Format: Article
Language:English
Subjects:
Alkaline Phosphatase - blood
Biological and medical sciences
Bone and Bones - metabolism
Calcitonin - blood
Calcium - metabolism
Calcium-Binding Proteins - blood
Child
Endocrine kidney. Renin-angiotensin-aldosterone system
Fundamental and applied biological sciences. Psychology
Humans
Male
Osteocalcin
Osteogenesis
Puberty
Testosterone - blood
Vertebrates: endocrinology
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container_issue 3
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container_title Calcified tissue international
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creator RIIS, B. J
KRABBE, S
CHRISTIANSEN, C
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DEFTOS, L. J
description In a longitudinal study of male puberty, 18 boys were examined every 3 months for at least 2 years. Serum bone Gla protein (BGP), a biochemical marker of bone formation, was determined and related to changes in serum testosterone (T), serum alkaline phosphatase (AP), serum calcitonin, and bone mineral content (BMC). The data demonstrate a steep increase in serum T during puberty (P less than 0.001), with an almost concomitant increase in serum BGP (P less than 0.001) and serum AP (P less than 0.001). Ten months after the maximal increase in serum T, the increase in BMC reached its maximum, whereas there was no significant change in the serum calcitonin. The data demonstrate that the steep increase in serum T during puberty, directly or indirectly, produces acute stimulation of bone formation (estimated from BGP and AP) followed by a highly significant increase in the integrated measurement of bone apposition (BMC).
doi_str_mv 10.1007/BF02554865
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source Springer Online Journal Archives
subjects Alkaline Phosphatase - blood
Biological and medical sciences
Bone and Bones - metabolism
Calcitonin - blood
Calcium - metabolism
Calcium-Binding Proteins - blood
Child
Endocrine kidney. Renin-angiotensin-aldosterone system
Fundamental and applied biological sciences. Psychology
Humans
Male
Osteocalcin
Osteogenesis
Puberty
Testosterone - blood
Vertebrates: endocrinology
title Bone turnover in male puberty: a longitudinal study
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