Increased in vivo secretory activity of neutrophil granulocytes in patients with psoriasis and palmoplantar pustulosis

The relationship between psoriasis and palmoplantar pustulosis (PPP) is uncertain, as is the role of the neutrophil granulocyte in these conditions. In a previous comparative study of the rate of polymorphonuclear leucocyte (PMN) phagocytosis of IgG- and IgG-C3b-coated particles, an increased uptake...

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Published in:Archives of Dermatological Research 1985-02, Vol.277 (3), p.179-184
Main Authors: LUNDIN, A, HAKANSSON, L, HALLGREN, R, MICHAELSSON, G, VENGE, P
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
beta 2-Microglobulin - metabolism
Biological and medical sciences
Chemotaxis, Leukocyte
Dermatology
Female
Foot Dermatoses - blood
Hand Dermatoses - blood
Humans
Lactoferrin - blood
Male
Medical sciences
Middle Aged
Muramidase - blood
Neutrophils - immunology
Neutrophils - metabolism
Phagocytosis
Psoriasis - blood
Psoriasis. Parapsoriasis. Lichen
Suppuration
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Summary:The relationship between psoriasis and palmoplantar pustulosis (PPP) is uncertain, as is the role of the neutrophil granulocyte in these conditions. In a previous comparative study of the rate of polymorphonuclear leucocyte (PMN) phagocytosis of IgG- and IgG-C3b-coated particles, an increased uptake rate was found in both diseases. Further information on the in vivo activity of PMNs in these conditions may be obtainable by determining the level of lactoferrin (LF) in serum from such patients, since LF serves as a specific marker of the turnover and activity of the circulating pool of neutrophils. In this study on 19 patients with psoriasis and 20 patients with PPP, elevated levels of LF were found in both conditions. In contrast, the levels of lysozyme and beta 2-microglobulin, which are markers of monocyte-macrophage and lymphocyte activity, respectively, were normal. This suggests the selective activation of neutrophils in these disorders. LF was significantly correlated (P less than 0.05 and 0.001, respectively) to the rates of phagocytosis of IgG- and IgG-C3b-coated particles, but not to the chemotaxis of isolated PMNs. There was no correlation between the severity of the disease and the levels of serum LF. The data suggest the increased in vivo activity of neutrophils in psoriasis and PPP.
ISSN:0340-3696
1432-069X
DOI:10.1007/BF00404313